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F3401

Supelco

2-Fluoroaniline

≥99%

Synonyme(s) :

1-Amino-2-fluorobenzene

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About This Item

Formule linéaire :
FC6H4NH2
Numéro CAS:
348-54-9
Poids moléculaire :
111.12
Numéro Beilstein :
1524219
Numéro CE :
206-478-9
Numéro MDL:
MFCD00007642
Code UNSPSC :
12352116
ID de substance PubChem :
24894844
Nomenclature NACRES :
NA.25

Pureté

≥99%

Indice de réfraction

n20/D 1.544 (lit.)

Point d'ébullition

182-183 °C (lit.)

Pf

−29 °C (lit.)

Densité

1.151 g/mL at 25 °C (lit.)

Chaîne SMILES 

Nc1ccccc1F

InChI

1S/C6H6FN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2

Clé InChI

FTZQXOJYPFINKJ-UHFFFAOYSA-N

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Actions biochimiques/physiologiques

The metabolism and excretion of the xenobiotic compound 2-fluoroaniline is important due to human exposure in manufacturing. It is found to be very efficiently metabolized, primarily by 4-hydroxylation with subsequent sulfate or glucuronide formation. N-Acetylation is also observed. At least 80% of the dose is excreted in the urine within 24 hr. 2-Fluoroaniline exerts its nephrotoxic effect through 4-hyroxylation and subsequent p-benzoquinonimine formation.

Mention d'avertissement

Danger

Mentions de danger

H226,H302,H314,H373,H410

Classification des risques

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1C - STOT RE 2

Organes cibles

Blood,hematopoietic system

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

140.0 °F - closed cup

Point d'éclair (°C)

60 °C - closed cup

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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M A Valentovic et al.
Toxicology, 75(2), 121-131 (1992-11-01)
Aniline and its halogenated derivatives are widely used as chemical intermediates. The purpose of this study was to determine the hepatotoxic and nephrotoxic potential of the 2-haloanilines. Male Fischer 344 rats (n > or = 4) were injected (i.p.) with
M Arivazhagan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 668-676 (2012-08-14)
The Fourier transform infrared (FT-IR) and Fourier transform Raman (FT-Raman) spectra of 4-chloro-2-fluoroaniline (CFA) have been recorded and analyzed. The equilibrium geometry, bonding features and harmonic vibrational frequencies have been investigated with the help of ab initio and density functional
A L Sharma et al.
Applied biochemistry and biotechnology, 96(1-3), 155-165 (2002-01-11)
Poly(2-fluoroaniline) was prepared by both chemical and electrochemical polymerization in acidic medium. Characterization of poly(2-fluoroaniline) was accomplished experimentally using ultraviolet-visible, Fourier transform infrared, differential scanning calorimetry, thermal gravimetric analysis, and X-ray diffraction techniques, respectively. Scanning electron microscopy studies revealed globular
Suria Jahan et al.
Transfusion, 60(4), 769-778 (2020-03-19)
Platelet engraftment following cord blood (CB) transplantation remains a significant hurdle to this day. The uncontrolled growth of ice, a process referred to as ice recrystallization, is one of several mechanisms that lead to cell loss and decreased potency during
J Vervoort et al.
NMR in biomedicine, 4(6), 255-261 (1991-12-01)
The present study describes results from an in vivo 19F NMR study on rats exposed to the xenobiotic compound 2-fluoroaniline. Qualitative pharmacokinetics and the biotransformation of 2-fluoroaniline were studied after exposure to 50 mg/kg body wt 2-fluoroaniline. Accumulation and elimination
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