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The solution stability of this product has not been determined internally. However, external sources state solutions of Biotin-PEG3-azide are stable at 80°C for 6 months and -20°C for 1 month.
762024
Azide-PEG3-biotin conjugate
Synonyme(s) :
Polyethylene glycol, N-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]hexahydro-2-oxo-(3aS,4S,6aR)- 1H-thieno[3,4-d ]imidazole-4-pentanamide, Biotin-PEG3-azide
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About This Item
Formule empirique (notation de Hill):
C18H32N6O5S
Numéro CAS:
Poids moléculaire :
444.55
Numéro MDL:
Code UNSPSC :
12352125
ID de substance PubChem :
Nomenclature NACRES :
NA.22
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Forme
solid
Niveau de qualité
Capacité de réaction
reaction type: click chemistry
Température de stockage
−20°C
Chaîne SMILES
O=C1N[C@](CS[C@H]2CCCCC(NCCOCCOCCOCCN=[N+]=[N-])=O)([H])[C@]2([H])N1
InChI
1S/C18H32N6O5S/c19-24-21-6-8-28-10-12-29-11-9-27-7-5-20-16(25)4-2-1-3-15-17-14(13-30-15)22-18(26)23-17/h14-15,17H,1-13H2,(H,20,25)(H2,22,23,26)/t14-,15-,17-/m1/s1
Clé InChI
ZWFOOMQCYIGZBE-BFYDXBDKSA-N
Application
Azide-PEG3-biotin conjugate has been used for the detection of a cellular alkyne cholesterol analog via click chemistry using fluorescence microscopy after incubation with a fluorescent streptavidin-conjugate.[1] It has also been used to prepare a novel multifunctional benzophenone linker that can be used for pull-down assays, photoaffinity labeling and double-click stapling techniques.[2]
Biotinylation reagent for labeling alkyne containing molecules or biomolecules using either copper-catalyzed 1,3 dipolar cycloaddition click chemistry or copper-free click chemistry with cyclooctyne derivatives. The azide group reacts with alkynes to form a stable triazole linkage facilitating the introduction of biotin into your alkyne modified system of interest. This reaction is bioorthogonal or in other words compatible with biological systems in that it′s components do not react with the biological environment.
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Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Les clients ont également consulté
Chapter Five-Mapping Lysine Acetyltransferase?Ligand Interactions by Activity-Based Capture
Montgomery DC & Meier JL
Methods in Enzymology, 574, 105-123 (2016)
Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling
Wu Y, et al.
Chembiochem, 17(8), 689-692 (2016)
Isotope-targeted glycoproteomics (IsoTaG) analysis of sialylated N-and O-glycopeptides on an Orbitrap Fusion Tribrid using azido and alkynyl sugars.
Woo CM, et al.
Analytical and Bioanalytical Chemistry, 409(2), 579-588 (2017)
A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization.
Hofmann K, et al.
Journal of Lipid Research, 55(3), 583-591 (2014)
Qingfei Zheng et al.
The Journal of organic chemistry, 85(3), 1691-1697 (2019-12-26)
Methylglyoxal (MGO) is a reactive dicarbonyl metabolite that modifies histones in vivo and induces changes in chromatin structure and function. Here we report the synthesis and application of a chemical probe for investigating MGO-glycation. A two-step synthesis of a Cu-click
Articles
Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.
Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.
Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.
Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.
Contenu apparenté
Polyethylene glycol (PEG), also sometimes referred to as polyethylene oxide (PEO), is a condensation polymer of ethylene oxide and water that has several chemical properties that make it useful for biological, chemical and pharmaceutical applications.
Polyethylene glycol (PEG), also sometimes referred to as polyethylene oxide (PEO), is a condensation polymer of ethylene oxide and water that has several chemical properties that make it useful for biological, chemical and pharmaceutical applications.
Polyethylene glycol (PEG), also sometimes referred to as polyethylene oxide (PEO), is a condensation polymer of ethylene oxide and water that has several chemical properties that make it useful for biological, chemical and pharmaceutical applications.
Polyethylene glycol (PEG), also sometimes referred to as polyethylene oxide (PEO), is a condensation polymer of ethylene oxide and water that has several chemical properties that make it useful for biological, chemical and pharmaceutical applications.
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Can I aliquot Azide-PEG3-biotin after it is dissolved in buffer and store at -20deg? Is it stable?
1 answer-
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Dear Sir or Madam, I ordered your compound Azide-PEG3-biotin and I just wanted to know what is the best solvent to resuspend it in?
1 answer-
This product is not tested for solubility, however, other sources state that this material is soluble in DMSO, DMF, Acetonitrile, water, and PBS. The published rates are variable, but range from 40 mg/mL in DMSO and water, to 10 mg/ml in PBS. This information has not been validated.
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