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752568

Sigma-Aldrich

Gold nanoparticles

5 nm diameter, OD 1, stabilized suspension in 0.1 mM PBS, reactant free

Synonyme(s) :

Au NP, Gold colloid

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About This Item

Numéro MDL:
MFCD00003436
Code UNSPSC :
12352302
ID de substance PubChem :
329766292
Nomenclature NACRES :
NA.23
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Niveau de qualité

200

Forme

nanoparticles
suspension

Concentration

~5.5E+13 particles/mL

DO

1

Diamètre

5 nm

λmax

510-520 nm

Température de stockage

2-8°C

Chaîne SMILES 

[Au]

InChI

1S/Au

Clé InChI

PCHJSUWPFVWCPO-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Goldnanoparticles with size of 5 nm and polydispersity index of <0.2 offer unique characteristics and have diverse applications in various industries. PBS maintains a physiological pH and prevents aggregation of nanoparticles. Smaller nanoparticles exhibit unique optical properties, including a strong surface plasmon resonance (SPR), which can be utilized in imaging and sensing applications. Small size also allows for enhanced permeability and retention effect in tumors, making them effective carriers for targeted drug delivery.

Application

  • Gold nanoparticles: Synthesis properties and applications: A comprehensive overview of the methods for synthesizing gold nanoparticles and their broad range of applications (I Hammami, NM Alabdallah, 2021).

Informations légales

Product of CytoDiagnostics, Inc.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
MKCW6834
MKCV2726
MKCT7412
MKCQ7766
MKCS6319

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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Articles

Sensitivity Lateral Flow Diagnostic Assays

Steven J. Oldenburg, Ph.D. provides an overview of lateral flow diagnostic assays and discusses the use of ultra-bright reporter particles based on the unique optical properties of gold nanoshells that significantly increase the sensitivity of lateral flow immunoassays.

Sensitivity Lateral Flow Diagnostic Assays

Steven J. Oldenburg, Ph.D. provides an overview of lateral flow diagnostic assays and discusses the use of ultra-bright reporter particles based on the unique optical properties of gold nanoshells that significantly increase the sensitivity of lateral flow immunoassays.

Surface-enhanced Solar Energy Conversion Systems

Sustainable energy sources with high production efficiency are crucial for meeting increasing energy demand.

Sensitivity Lateral Flow Diagnostic Assays

Steven J. Oldenburg, Ph.D. provides an overview of lateral flow diagnostic assays and discusses the use of ultra-bright reporter particles based on the unique optical properties of gold nanoshells that significantly increase the sensitivity of lateral flow immunoassays.

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Questions

1–10 of 14 Questions  

  1. What is the composition and pH of 0.1mM PBS?

    1 answer

    1. The pH of this product is not determined. Based on the product page, the only listed components are Gold nanoparticles in 0.1 mM phosphate-buffered saline (PBS). Any other components are considered proprietary.

      Helpful?

  2. Could you please confirm whether the nanoparticles are sterile and are suitable for cell-based experiments? If not sterile, what recommended sterilization method should I use to ensure their sterility?

    1 answer

    1. This product is not sterile. Please see the links below to publications that offer information on sterilization of gold nanoparticles:
      https://pubs.acs.org/doi/10.1021/acs.langmuir.2c01557#:~:text=3.3.-,1.,C%20for%20about%2020%20min.
      https://pubs.acs.org/doi/10.1021/acs.langmuir.2c01557
      https://pubmed.ncbi.nlm.nih.gov/19937607/

      Helpful?

  3. What is the Z potential of the nanoparticles?

    1 answer

    1. The product in question has a net negative charge with a zeta potential in the range of –20mV to –30mV.

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  4. Which gold nanoparticle size should I choose for my application?

    1 answer

    1. The size of gold nanoparticle to use is very depandent upon the intended application. Generally, smaller particles offer better sensitivity in applications such as immunogold labeling due to less steric hindrance and the ability to bind more gold nanoparticles to the desired target. Small gold nanoparticles are less visible than larger particles, however, which must also be taken into account.As an application example, particles with a size between 30-50nm are particularly useful for the development of rapid tests such as lateral flow assays.

      Helpful?

  5. How do you attach gold nanoparticles to oligos?

    1 answer

    1. To attach gold nanoparticles to oligos please view the information in the attached reference - Bioconjug Chem. 2011 Apr 20;22(4):794-807. Epub 2011 Mar 28.

      Helpful?

  6. How do you attach gold nanoparticles to glass?

    1 answer

    1. To view the procedure on how to attach gold nanoparticles to glass please view information in the reference - Journal of Atomic, Molecular, and Optical PhysicsVolume 2012 (2012). Article ID 683830, 6 pagesdoi:10.1155/2012/683830

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  7. What is the shape of the gold nanoparticles?

    1 answer

    1. The majority (>95%) of the gold nanoparticles are spherical.

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  8. Why does my gold nanoparticle solution turn violet when I add salt containing buffer?

    1 answer

    1. Due to repulsive forces arising from the surface charge of gold nanoparticles, an energy barrier must be overcome for individual particles to interact. When no (or small) amounts of electrolytes such as NaCl is present, this energy barrier is too strong for interaction to occur between particles. However, upon addition of NaCl this energy barrier is reduced allowing the gold nanoparticles to interact and aggregate. This aggregation causes a phenomenon called surface-plasmon coupling which changes the adsorption maximum of light to a higher wavelength resulting in a change in color of the solution.

      Helpful?

  9. Do I need to wash my gold nanoparticles?

    1 answer

    1. For most applications, our gold nanoparticles can be used without any additional washing steps. If you have a sensitive application that requires additional washing the best way to do so is by either centrifugation or filtration.

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  10. Can the Gold nanoparticles be frozen?

    1 answer

    1. No, the Gold nanoparticles should not be frozen.  If frozen, the gold nanoparticles will irreversibly aggregate, turning the solution clear.

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1–10 of 14 Questions  

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