Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer.

Cancer letters (2012-10-04)

Himashinie V K Diyabalanage, Michael L Granda, Jacob M Hooker

RÉSUMÉ

One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in vivo in recent studies for many cancer types and stages. In this review, we discuss the most commonly used combinations of histone deacetylase inhibitors and platinum based drugs in the context of their possible mechanisms, efficiency, efficacy, and related drawbacks in preclinical and clinical studies.

MATÉRIAUX

Référence du produit

Marque

Description du produit

298093

Sigma-Aldrich

Platinum, gauze, 100 mesh, 99.9% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

327492

Sigma-Aldrich

Platinum, wire, diam. 1.0 mm, 99.9% trace metals basis

267201

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.99% trace metals basis

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

204013

Sigma-Aldrich

Platinum, powder, 99.995% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

298107

Sigma-Aldrich

Platinum, gauze, 52 mesh, 99.9% trace metals basis

267228

Sigma-Aldrich

Platinum, wire, diam. 0.5 mm, 99.9% trace metals basis

685453

Sigma-Aldrich

Platinum, nanopowder, <50 nm particle size (TEM)

520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

349356

Sigma-Aldrich

Platinum, foil, thickness 0.05 mm, 99.99% trace metals basis

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

357367

Sigma-Aldrich

Platinum, wire, diam. 0.10 mm, 99.99% trace metals basis

267171

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.99% trace metals basis

GF49364264

Platinum, wire reel, 1m, diameter 0.5mm, as drawn, 99.99+%

771937

Sigma-Aldrich

Platinum, nanopowder, 200 nm particle size (SEM), 99.9% (metals basis)

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

GF98759200

Platinum, foil, not light tested, 100x100mm, thickness 0.0125mm, as rolled, 99.95%

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

267163

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.99% trace metals basis

349372

Sigma-Aldrich

Platinum, foil, thickness 1.0 mm, 99.99% trace metals basis

GF80394914

Platinum, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.99+%

GF60279576

Platinum, foil, 25x25mm, thickness 0.25mm, as rolled, 99.95%

GF21250594

Platinum, tube, 100mm, outside diameter 0.95mm, inside diameter 0.60mm, wall thickness 0.175mm, as drawn, 99.95%

204048

Sigma-Aldrich

Platinum, powder (coarse), 99.99% trace metals basis

GF22473941

Platinum, wire reel, 10m, diameter 0.025mm, hard, 99.9%

373265

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, thermocouple grade

GF90182257

Platinum, foil, 25x25mm, thickness 0.1mm, as rolled, 99.99+%

GF02251730

Platinum, rod, 200mm, diameter 1.0mm, 99.95%