SML2019

DS44170716

≥98% (HPLC)

• Synonyme(s) : (3aR,4S,9bS)-rel-8-bromo-3a,4,5,9b-tetrahydro-4-(4-methylphenyl)-3H-cyclopenta[c]quinoline-6-carboxylic acid, 8-Bromo-3a,4,5,9b-tetrahydro-4-(4-methylphenyl)-3H-cyclopenta[c]quinoline-6-carboxylic acid
• Formule empirique (notation de Hill) : C₂₀H₁₈BrNO₂
• Numéro CAS: 486993-62-8
• Poids moléculaire : 384.27
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear (warmed)
• Température de stockage: 2-8°C

Description

Actions biochimiques/physiologiques

DS44170716 is an inhibitor of Ca2+-induced mitochondrial permeability transition. It has a different mechanism of action from cyclosporin A that is not dependent on PPIF, a peptidyl-prolyl cis-trans isomerase associated with the mitochondrial permeability transition pore (MPTP). Instead DS44170716 blocks Ca2+ flux into the mitochondria by decreasing mitochondrial membrane potential and inhibits enzyme activities of mitochondrial respiratory chain complex III, IV and V. It showed a similar potent protective effect against Ca2+-induced death in human liver cells as Cyclosporin A.

Inhibitor of Ca2+-induced mitochondrial permeability transition

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319
• Conseils de prudence: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable