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Principaux documents

SCP0038

Sigma-Aldrich

Amyloid β 1-42 rat

≥90% (HPLC)

Synonyme(s) :

β-Amyloid 1-42, Amyloid for Rat, Rat Amyloid β 1-42

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500 μG
480,00 $
1 MG
710,00 $

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Changer de vue
500 μG
480,00 $
1 MG
710,00 $

About This Item

Formule empirique (notation de Hill) :
C199H307N53O59S1
Poids moléculaire :
4417.95
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32

480,00 $

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Devis pour commande en gros

Essai

≥90% (HPLC)

Forme

lyophilized

Composition

Peptide Content, ≥75%

Conditions de stockage

protect from light

Température de stockage

−20°C

Amino Acid Sequence

Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

Description générale

Amyloid β (Aβ) 1-42 is the major Aβ species in the amyloid plaques that develop in the case of Alzheimer′s disease (AD). It has a cross-β structure with parallel, in-register β-sheets.

Application

Amyloid β 1-42 rat has been used as an amyloid β (Aβ) oligomer in intracerebroventricular (ICV) injection/intra-hippocampal infusion to establish the Alzheimer′s disease (AD) model in rat.

Actions biochimiques/physiologiques

Amyloid β 1-42 forms amyloid fibrils more readily compared to Aβ(1–40), in vitro. Aβ1-42 injections are known to cause brain dysfunction indicating learning and memory deficits. Amyloid β (Aβ) refers to peptides derived from amyloid precursor protein that vary in length from 37–43 amino acids. Aβ(s) peptides, their peptide fragments, and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding, and mechanisms of protein cross-linking in the context of diseases such as Alzheimer′s disease and neurodegeneration.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
E1375
E1327
E1271
E1246
E1221

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Jing Wang et al.
Molecular medicine reports, 23(6) (2021-04-22)
Ginkgolide B (GB), the diterpenoid lactone compound isolated from the extracts of Ginkgo biloba leaves, significantly improves cognitive impairment, but its potential pharmacological effect on astrocytes induced by β‑amyloid (Aβ)1‑42 remains to be elucidated. The present study aimed to investigate the
Volodymyr A Yavorsky et al.
Frontiers in cellular neuroscience, 17, 1132092-1132092 (2023-05-01)
One of the signs of Alzheimer's disease (AD) is the formation of β-amyloid plaques, which ultimately lead to the dysfunction of neurons with subsequent neurodegeneration. Although extensive researches have been conducted on the effects of different amyloid conformations such as
Enes Akyuz et al.
Biomedicines, 8(3) (2020-03-19)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a complex etiology and characterized by cognitive deficits and memory loss. The pathogenesis of AD is not yet completely elucidated, and no curative treatment is currently available. Inwardly rectifying potassium (Kir)
Ruo-Meng Li et al.
Neural regeneration research, 18(6), 1347-1353 (2022-12-02)
Previous studies have shown that fibroblast growth factor 13 is downregulated in the brain of both Alzheimer's disease mouse models and patients, and that it plays a vital role in the learning and memory. However, the underlying mechanisms of fibroblast
Rat Hair Metabolomics Analysis Reveals Perturbations of Unsaturated Fatty Acid Biosynthesis, Phenylalanine, and Arachidonic Acid Metabolism Pathways Are Associated with Amyloid-I?-Induced Cognitive Deficits.
Tan, et al.
Molecular Neurobiology (2023)
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Questions

  1. What's the preparation instruction and how long is the incubation period?

    1 answer

    1. This product has not been tested for solubility or in vitro use. However there are publications available that may be helpful. Please see the information and links to the articles below:

      Aβ1-42 was dissolved in sterile water at a concentration of 2 mmol/L and incubated at 37 °C for 24 h.
      https://www.nature.com/articles/aps2013203

      A solution of 200 ng/μL concentration of Aβ was prepared in PBS (0.1 M). The solution of Aβ was incubated for 5 days at 37⁰C, and before injection, PBS was added to the solution to reach a final concentration of 10 ng/μL.
      https://www.researchgate.net/publication/346096849_Original_Article_Improvement_of_Learning_and_Memory_Deficits_With_Aerobic_Training_and_Donepezil_Co-therapy_in_Amyloid-b_beta-injected_Male_Rats_Through_the_CREB_and_BDNF_Signaling_Pathway

      Helpful?

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