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SAB4502019

Sigma-Aldrich

Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

NOTC1, Notch homolog 1, neurogenic locus notch 1, notch 1 (translocation-associated), translocation-associated (Drosophila) (TAN1)

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 110 kDa

Espèces réactives

rat, mouse, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P46531

Numéro d'accès UniProt

P46531

Application(s)

research pathology

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

proteolytically cleaved (Val1754)

Informations sur le gène

human ... NOTCH1(4851)

Description générale

The NOTCH1 gene is mapped to human chromosome 9q34 and encodes a member of the NOTCH family of proteins. The gene encodes a large transmembrane protein that contains an extracellular domain with 36 tandem epidermal growth factor (EGF)-like repeats and three cysteine-rich Notch/LIN-12 repeats, a six ankyrin repeat-containing intracellular domain, and a transactivation domain.

Anti-NOTCH1 (Cleaved-Val1754) Antibody detects endogenous levels of fragment of activated NOTCH1 (Cleaved-Val1754) protein.

Immunogène

The antiserum was produced against synthesized peptide derived from human Notch 1.

Immunogen Range: 1735-1784

Application

Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit has been used in immunohistochemistry (IHC).

Actions biochimiques/physiologiques

The Notch1 protein is a transmembrane receptor that induces pluripotent progenitor cells to form T-cells and facilitates the assembly of pre–T cell receptor complexes in immature thymocytes. It participates in an intracellular signaling pathway that regulates cellular differentiation, cell fate and lateral inhibition. Mutations in this gene have been associated with human blood cancers, abnormal cardiovascular calcification, aortic valve disease, and human T cell acute lymphoblastic leukemia.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Takaya Shiraishi et al.
International journal of molecular medicine, 44(4), 1574-1584 (2019-08-01)
The Notch receptor serves a fundamental role in the regulation of cell fate determination through intracellular signal transmission. Mutation of the Notch receptor results in abnormal active signaling, leading to the development of diseases involving abnormal cell growth, including malignant
Yan Li et al.
Bioengineered, 12(2), 10183-10193 (2021-12-08)
As the second most common cancer among women, cervical cancer is a huge threat to their health all over the world. Integral membrane protein 2A (ITM2A), a member of the Type II Integral Membrane protein (ITM2) family, has been reported
Yu-Wen Cao et al.
International journal of clinical and experimental pathology, 7(7), 4286-4294 (2014-08-15)
Accumulated evidence has revealed the presence of Notch receptor polymorphisms in non-tumorous diseases; however, few studies have investigated the association of Notch polymorphisms with breast cancer risk. A total of 100 invasive ductal carcinoma (IDC) and 50 ductal carcinoma in
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Weng A P, et al.
Science, 306(5694), 269-271 (2004)
Mutations in NOTCH1 cause aortic valve disease.
Garg V, et al.
Nature, 437(7056), 270-270 (2005)
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