SAB4500500

Anti-CSFR antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : CD115, CSF-1-R, CSF1R, CSFMR, c-fms
• Numéro MDL: MFCD00282160
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 107 kDa
• Espèces réactives: human, rat, mouse
• Concentration: ~1 mg/mL
• Technique(s): ELISA: 1:5000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100
• Numéro d'accès NCBI: P07333
• Numéro d'accès UniProt: P07333
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CSF1R(1436)

Description

Description générale

Colony stimulating factor 1 receptor (CSF-1R) is encoded by the c-fms proto-oncogene mapped to human chromosome 5q33. The encoded protein acts as a receptor for CSF1 expressed in non-hematopoietic cells, such as macrophages, epithelial and fibroblasts cells and tumor cells.

Immunogène

The antiserum was produced against synthesized peptide derived from human CSFR.

Immunogen Range: 531-580

Actions biochimiques/physiologiques

Colony stimulating factor 1 receptor (CSF-1R)/ CSF-1 ligand system plays a vital role in the regulation of macrophage physiology in immune system.The encoded protein functions as a receptor and mediates the function of its ligand, colony stimulating factor 1, a cytokine involved in regulation of production, differentiation, and function of macrophages. Experimental analysis revealed that CSF-1/CSF-1R is overexpressed in patients with nasopharyngeal carcinoma when compared to patients with nasopharyngitis. Activated CSF-1R, is essential for monocyte differentiation to macrophages by oxidized low-density lipoprotein (Ox-LDL), which is a vital step in early atherogenesis. This protein is also associated with regulation of hematopoiesis. Deletion or mutation of this gene might be involved in the pathogenesis of myelodysplastic syndromes or of acute nonlymphocytic leukemia (ANLL).

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable