SAB2702004

Anti-PPP1CB antibody produced in rabbit

• Synonyme(s) : PP-1B, PP1B, PP1beta, PPP1CD
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: liquid
• Poids mol.: 37 kDa
• Espèces réactives: human, mouse
• Concentration: 0.5 mg/mL
• Technique(s): immunocytochemistry: suitable; immunofluorescence: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; western blot: 500-3000
• Numéro d'accès UniProt: P62140
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... PPP1CB(5500)

Description

Description générale

Protein phosphatase 1 catalytic subunit β (PPP1CB) gene is mapped to human chromosome 2p23.2. It is expressed in spines, dendrites, axon terminals, axons and glia in the prefrontal cortex. PPP1CB is expressed at higher levels in dendrites. It has a calcineurin-like phosphoesterase domain, a metallophosphatase domain and a serine/threonine protein phosphatase domain.

Immunogène

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 274 of PPP1CB

Application

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-Fr: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Actions biochimiques/physiologiques

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.
In the brain, protein phosphatase 1 catalytic subunit β (PPP1CB) regulates synaptic plasticity. Mutation in the gene causes intellectual disability (ID), congenital heart disease.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H317,H412
• Conseils de prudence: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Classification des risques: Aquatic Chronic 3 - Skin Sens. 1
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable