SAB2500547

Anti-ITGAM antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonyme(s) : Anti-α-M (complement component 3 receptor 3 subunit), Anti-CD11B, Anti-CR3A, Anti-Integrin, Anti-MAC-1
• Numéro MDL: MFCD00240630
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: goat
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Espèces réactives: human
• Technique(s): ELISA: suitable; immunofluorescence: suitable; immunohistochemistry: suitable
• Numéro d'accès UniProt: P11215
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... ITGAM(3684)

Description

Description générale

Integrin α M (ITGAM) is also called as cluster of differentiation 11b (CD11b) or intercellular adhesion molecule-1 (ICAM-1). It is expressed on monocytes/macrophages, natural killer cells, neutrophils and a subset of B-and T-lymphocytes. ITGAM gene is located on human chromosome 16p11.

Immunogène

Peptide with sequence C-RNDGEDSYRTQ from the internal region of the protein sequence according to NP_000623.2 .

Actions biochimiques/physiologiques

Integrin α M (ITGAM) is involved in cell activation, chemotaxis, cytotoxicity and phagocytosis. It modulates the interaction of leukemic cells with microenvironment by binding inactivated complement component 3b (iC3b), intercellular adhesion molecule (ICAM), fibrinogen, beta-glukanes, coagulation factor X etc. ITGAM is considered as a marker for myeloid-derived suppressor cells that participates in restraining antitumor immunity of the host and inducing the enlargement and drug-resistance of hematological malignant cells. D11b integrin contributes to ICAM-1-dependent AIDP patient mononuclear leukocyte adhesion.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable