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SAB1302240

Sigma-Aldrich

ANTI-MOUSE NLRP6 (CENTER) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonyme(s) :

LRR and PYD domains-containing protein 6, NACHT, Nalp6, Nlrp6, Pypaf5

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

97402 Da

Espèces réactives

mouse

Technique(s)

western blot: 1:1000

Numéro d'accès UniProt

Q91WS2

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Nlrp6(101613)

Description générale

NLR family, pyrin domain containing 6 (NLRP6) maybe part of the inflammasome. It belongs to the Nod-like receptor family and is expressed in intestinal epithelial cells.

Actions biochimiques/physiologiques

NLR family, pyrin domain containing 6 (NLRP6) has a role in innate immunity. It also maintains intestinal homeostasis by modulating autophagy and mucus secretion. Loss of NLRP6 has been shown to hinder the production of interleukin-18 (IL-18) and enhance susceptibility to epithelial-induced injury in rats.

Forme physique

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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NLRP6 Protects Il10-/- Mice from Colitis by Limiting Colonization of Akkermansia muciniphila.
Seregin SS
Cellular Reprogramming (2017)
Pierre-Gregoire Coulon et al.
Frontiers in immunology, 10, 1631-1631 (2019-08-02)
The crosstalk between the host's inflammasome system and the invading virulent/less-virulent viruses determines the outcome of the ensuing inflammatory response. An appropriate activation of inflammasomes triggers antiviral inflammatory responses that clear the virus and heal the inflamed tissue. However, an
NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury.
Seregin SS
Mucosal Immunology (2017)
Lanqing Sun et al.
Heliyon, 10(8), e28432-e28432 (2024-04-17)
Non-typhoidal Salmonella infection is among the most frequent foodborne diseases threatening human health worldwide. The host circadian clock orchestrates daily rhythms to adapt to environmental changes, including coordinating immune function in response to potential infections. However, the molecular mechanisms underlying
Qifeng Deng et al.
Redox biology, 49, 102217-102217 (2021-12-24)
Maintaining host iron homeostasis is an essential component of nutritional immunity responsible for sequestrating iron from pathogens and controlling infection. Nucleotide-oligomerization domain-like receptors (NLRs) contribute to cytoplasmic sensing and antimicrobial response orchestration. However, it remains unknown whether and how NLRs
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