The solubility specification was tested at 100 mg/ml in 1 M NaOH (refer to the specification sheet). Probenecid is soluble in chloroform, in dilute solutions of sodium hydroxide, then buffered to pH 7.4, and is nearly insoluble in water. It is also soluble in 1 M NaOH (50 mg/ml), producing a clear, colorless solution.
P8761
Probenecid
≥98% (NaOH, titration), powder, uricosuric agent
Synonyme(s) :
p-(Dipropylsulfamoyl)benzoic acid
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About This Item
Formule empirique (notation de Hill) :
C13H19NO4S
Numéro CAS:
Poids moléculaire :
285.36
Numéro CE :
Numéro MDL:
Code UNSPSC :
12161501
ID de substance PubChem :
Nomenclature NACRES :
NA.77
Produits recommandés
Nom du produit
Probenecid,
Essai
≥98% (NaOH, titration)
Auteur
Merck & Co., Inc., Kenilworth, NJ, U.S.
Chaîne SMILES
CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
InChI
1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
Clé InChI
DBABZHXKTCFAPX-UHFFFAOYSA-N
Informations sur le gène
human ... SLC22A11(55867) , SLC22A6(9356) , SLC22A8(9376)
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Application
Probenecid has been used:
- as a component of phenol red free Hank′s buffer for Intracellular Ca2+-mobilization assay[1]
- as a component of calcium sensitive dye for calcium mobilization Studies[2]
- as a supplement in Hank′s balanced salt solution (HBSS) assay buffer[3]
Useful as an inhibitor of the organic anion transporter, MRP.
Actions biochimiques/physiologiques
Probenecid is a uricosuric agent, which increases uric acid removal in the urine[4] and reduces urate reuptake.[5] It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout.[5] Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma.[4]
Caractéristiques et avantages
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Gloves
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Articles
Protein-based drug transporters are expressed in Sf9 cells. Understanding the specific mechanisms of tumor cell transporters is an essential aspect of chemotherapeutic drug design.
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