Soluble at 50mg/ml, it can be dissolved in water, but it is recommended to use saline, NaCl, DPBS, Hanks, or culture medium. Please note that a reference in peer- reviewed papers at sial.com isolated glomerular endothelial cells at 0.1% in DMEM. This paper may also be of reference "Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells (https://www.sciencedirect.com/science/article/pii/S0006291X02006939?via%3Dihub)
P5515
Prostaglandin E1
≥98% (HPLC), powder, vasodilator
Synonyme(s) :
(11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE1
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1 MG
216,00 $
5 MG
672,00 $
10 MG
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Changer de vue
1 MG
216,00 $
5 MG
672,00 $
10 MG
958,00 $
About This Item
Formule empirique (notation de Hill) :
C20H34O5
Numéro CAS:
Poids moléculaire :
354.48
Beilstein:
5294062
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352211
eCl@ss :
42020658
ID de substance PubChem :
Nomenclature NACRES :
NA.77
216,00 $
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Nom du produit
Prostaglandin E1, ≥98% (HPLC), synthetic
Source biologique
synthetic
Essai
≥98% (HPLC)
Forme
(powder to crystals)
Solubilité
ethanol: 5 mg/mL
Température de stockage
−20°C
Chaîne SMILES
O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1
InChI
1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
Clé InChI
GMVPRGQOIOIIMI-DWKJAMRDSA-N
Informations sur le gène
human ... PTGER1(5731) , PTGER2(5732) , PTGIR(5739)
mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)
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Application
Actions biochimiques/physiologiques
Prostaglandin E1 (PGE1) is a hormone synthesized from dihomo-γ-linolenic acid (DGLA) by the action of enzyme prostaglandin synthase.[4] It is a vasodilator and activates adenylate cyclase. It is majorly present in human semen and is a potent platelet aggregation inhibitor. PGE1 infusions is effective in treating limb ischemia and peripheral vascular disease.[5] It is unstable and is hydrolyzed to PGA1 in the lungs. Nanoparticle encapsulation of PGE1 is essential for its delivery at the vascular injury site.[6] It elicits vasodilator effects on the retinal artery and vein in central retinal artery occlusion (CRAO).[7] PGE1 and its synthetic analog misoprostol interact with E-prostanoid receptor 4 (EP4) and elicits protection in chronic myelogenous leukemia (CML). [8]
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 3 Oral
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Les clients ont également consulté
The crystal and molecular structure of prostaglandin E1
Spek, AL
Acta Crystallographica Section B, Structural Science, 33(3), 816-824 (1977)
Responses of the thyroid gland to TSH and other thyroid stimulators in the growth-retarded (grt) mouse
Kobayashi K, et al.
Zoological Science, 18(7), 955-962 (2001)
Dissection of autophagy in human platelets
Feng W, et al.
Autophagy, 10(4), 642-651 (2014)
Mélanie Abonnenc et al.
Blood transfusion = Trasfusione del sangue, 13(2), 255-264 (2014-11-05)
The Intercept Blood SystemTM (Cerus) is used to inactivate pathogens in platelet concentrates (PC). The aim of this study was to elucidate the extent to which the Intercept treatment modifies the functional properties of platelets. A two-arm study was conducted
Prostaglandin E1 and its analog misoprostol inhibit human CML stem cell self-renewal via EP4 receptor activation and repression of AP-1
Li F, et al.
Cell Stem Cell, 21(3), 359-373 (2017)
Articles
Discover Bioactive Small Molecules for Lipid Signaling Research
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Is stability in solution information available for the product P5515?
Is stability in solution information available for the product P5515?
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What are the recommended storage temperature conditions for Prostaglandin E1 (P5515) when dissolved in acetone?
1 answer-
The solubility test is designed to ensure the product is free of foreign bodies or other unsoluble substances. Acetone was choosen for the solubility test because appears to have higher solubility in acetone than it does in ethanol. The Quality department will dissolve the product in acetone and discard the solution once the solubility test is complete. So there is no data for what is the preferred storage temperature and length of storage if using acetone as the solvent.
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