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M7441

Sigma-Aldrich

Monoamine Oxidase B human

recombinant, expressed in baculovirus infected BTI insect cells

Synonyme(s) :

MAO-B

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1 VIAL
690,00 $
5 X 1 VIAL
2 390,00 $

690,00 $


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Changer de vue
1 VIAL
690,00 $
5 X 1 VIAL
2 390,00 $

About This Item

Numéro de classification (Commission des enzymes):
Numéro MDL:
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54

690,00 $


Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.

Produit recombinant

expressed in baculovirus infected BTI insect cells

Niveau de qualité

Forme

liquid

enzyme activity

≥1 U/mg

Conditionnement

vial of ~2.5 mg

Numéro d'accès UniProt

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... MAOB(4129)

Description générale

Monoamine Oxidase B is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs. [1]

Application

Drugs that inhibit monoamine oxidase B activity are used for the treatment of various neurological disorders including depression. [2]
Monoamine Oxidase B has been used in a study to assess the effect of age in 23 different regions of the human brain. [3] It has also been used in a study to determine the specific locations of monoamine oxidase in the human brain. [4]

Actions biochimiques/physiologiques

MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.

Définition de l'unité

kynuramine deamination activity: One unit will deaminate 1 nanomole of kynuramine per minute at pH 7.4 at 37 deg C.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

K N Westlund et al.
Neuroscience, 25(2), 439-456 (1988-05-01)
Monoclonal antibodies, specific for either monoamine oxidases A or B, were used to determine the localization of monoamine oxidase in the human brain. Two distinct populations of neurons were detected by immunocytochemical staining. Neurons in regions rich in catecholamines were
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda, C., et al.
Nature Structural Biology, 9, 22-26 (2001)
Aiko Ishiki et al.
Acta neuropathologica communications, 6(1), 53-53 (2018-07-01)
Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of progressive supranuclear palsy (PSP) cases. To confirm the binding target of radiotracer in PSP, we performed an imaging-pathology correlation study in
The effect of age on the activity and molecular properties of human brain monoamine oxidase
Fowler, C., et al.
Journal of Neural Transmission. General Section, 49, 1-20 (1980)
Dorota Łażewska et al.
Molecules (Basel, Switzerland), 26(12) (2021-07-03)
Neurodegenerative diseases, e.g., Alzheimer's disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but interconnected targets can

Questions

  1. What is the concentration?

    1 answer
    1. Each vial contains approximately 2.5 mg protein. The minimum protein concentration is 2.5 mg/mL. A survey of recent lots indicates a consistent concentration of 5.0 mg/mL. The minimum activity of this enzyme is 1 unit per milligram and varies considerably from lot to lot. This value is reported in the product Certificate of Analysis. Please see the link below to review a sample or lot-specific Certificate:
      https://www.sigmaaldrich.com/product/sigma/m7441#product-documentation

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