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L6520

Sigma-Aldrich

Prolactin from sheep pituitary

20-50 IU/mg

Synonyme(s) :

LTH, Lactogenic hormone from ovine pituitary glands, Luteotropic Hormone, PRL

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About This Item

Numéro CAS:
9002-62-4
Numéro MDL:
MFCD00131553
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32

Forme

powder

Activité spécifique

20-50 IU/mg

Solubilité

water: 7 mg/mL, clear to slightly hazy, colorless to faintly yellow

Numéro d'accès UniProt

P01240

Conditions d'expédition

ambient

Température de stockage

2-8°C

Informations sur le gène

sheep ... PRL(443317)

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Actions biochimiques/physiologiques

Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H360

Conseils de prudence

P201 - P308 + P313

Classification des risques

Repr. 1B

Code de la classe de stockage

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Timestrip Plus™ 8 °C

Supelco

08168

Timestrip Plus™ 8 °C

Jakub Sumbal et al.
Frontiers in cell and developmental biology, 8, 68-68 (2020-04-09)
Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma.
Sharon R Ladyman et al.
eLife, 10 (2021-09-17)
As part of the maternal adaptations to pregnancy, mice show a rapid, profound reduction in voluntary running wheel activity (RWA) as soon as pregnancy is achieved. Here, we evaluate the hypothesis that prolactin, one of the first hormones to change
Narattaphol Charoenphandhu et al.
American journal of physiology. Endocrinology and metabolism, 297(3), E609-E619 (2009-07-02)
During pregnancy and lactation, the enhanced intestinal Ca(2+) absorption serves to provide Ca(2+) for fetal development and lactogenesis; however, the responsible hormone and its mechanisms remain elusive. We elucidated herein that prolactin (PRL) markedly stimulated the transcellular and paracellular Ca(2+)
Khalid Bajou et al.
Nature medicine, 20(7), 741-747 (2014-06-16)
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor
Gerda de Kuijper et al.
Research in developmental disabilities, 34(9), 2799-2809 (2013-06-25)
Individuals with intellectual disability frequently use antipsychotics for many years. This may have detrimental health effects, including neurological symptoms and metabolic and hormonal dysregulation, the latter possibly affecting bone metabolism. There is large variability in the degree in which antipsychotic
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