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I7284

Sigma-Aldrich

Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-CD127, Anti-Il7r

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About This Item

Numéro MDL:
MFCD01864808
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.41

Source biologique

goat

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

mouse

Technique(s)

flow cytometry: 3.0-10.0 μg/mL
western blot: 0.1-0.2 μg/mL

Numéro d'accès UniProt

P16872

Température de stockage

−20°C

Informations sur le gène

mouse ... Il7r(16197)

Description générale

Interleukin-7 (IL-7) is a stromal-cell derived cytokine that is important in the development of adaptive immunity and maintenance of T cells and B cells. The cognate receptor that binds IL-7 is the IL-7 receptor complex, made up of IL-7 R α (CD127) chain and a γ chain. The expression of IL-7 R is restricted to immature B cells, mature T cells and thymocytes. The binding of IL-7 to its receptor triggers a variety of tightly regulated signaling pathways that are critical for cell survival, proliferation, differentiation and uptake of glucose. The signaling pathways that participate in mediating the effects of IL-7 R are JAK/STAT and PI3K. Additionally, the effect of IL-7 on cell cycle is due to the modulation of proteins p27kip1 and Cdc25A. Reports implicate IL-7 R in glucose metabolism and cell size as it modulates the effects of GLUT4. Anti-interleukin-7 receptor α/CD127 recognizes mouse IL-7 Rα. This antibody shows less than 1% cross reactivity with rhIL-7 Rα.

Immunogène

purified, NSO cell-derived recombinant mouse interleukin-7 soluble receptor α.

Application

Anti-interleukin-7 receptor α/CD127 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For flow cytometry, the recommended concentration is 3-10 μg/ml/6 cells.

Forme physique

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Christina Kittipatarin et al.
Cytokine, 39(1), 75-83 (2007-09-05)
The signaling processes that maintain the homeostatic proliferation of peripheral T-cells and result in their self-renewal largely remain to be elucidated. Much focus has been placed on the anti-apoptotic function of the cytokine, interleukin-7 (IL-7), during T-cell development. But a
Interleukin-7: from bench to clinic.
Terry J Fry et al.
Blood, 99(11), 3892-3904 (2002-05-16)
C Pallard et al.
Immunity, 10(5), 525-535 (1999-06-15)
Here, we define the IL-7R-activated signal that promotes survival and proliferation of T cell progenitors and demonstrate that it is distinct from the signals that induce differentiation. We show that IL-7 activates PKB and STAT5 in human thymocytes. Into T
Joao T Barata et al.
The Journal of experimental medicine, 200(5), 659-669 (2004-09-09)
Interleukin (IL)-7 is essential for normal T cell development. Previously, we have shown that IL-7 increases viability and proliferation of T cell acute lymphoblastic leukemia (T-ALL) cells by up-regulating Bcl-2 and down-regulating the cyclin-dependent kinase inhibitor p27kip1. Here, we examined
C Kittipatarin et al.
Cell cycle (Georgetown, Tex.), 5(9), 907-912 (2006-04-22)
A balance between survival and proliferative signals maintains a constant number of T lymphocytes that populate the mammalian immune system, a process termed "homeostasis". Central to this process is the availability of a stromal cell product--the cytokine interleukin-7 (IL-7). We
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