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H9791

Sigma-Aldrich

Hyp9

Synonyme(s) :

1,1′-(2,4,6-Trihydroxy-1,3-phenylene)bis-1-hexanone, 2,4-(bis-1-ketohexyl)phloroglucinol

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About This Item

Formule empirique (notation de Hill):
C18H26O5
Numéro CAS:
3118-34-1
Poids moléculaire :
322.40
Numéro MDL:
MFCD16875422
Code UNSPSC :
12352200
ID de substance PubChem :
329815271
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to light yellow

Solubilité

DMSO: >20 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

CCCCCC(=O)c1c(O)cc(O)c(C(=O)CCCCC)c1O

InChI

1S/C18H26O5/c1-3-5-7-9-12(19)16-14(21)11-15(22)17(18(16)23)13(20)10-8-6-4-2/h11,21-23H,3-10H2,1-2H3

Clé InChI

JRHOSBCIYWDGHN-UHFFFAOYSA-N

Actions biochimiques/physiologiques

Hyperforin is the active ingredient in St. John′s Wort. It is used to treat depression, known to indirectly inhibit reuptake of serotonin and norepinephrine at the synapse, and recently discovered to exert its actions by directly activating TRPC6. TRPC6 is a member of the canonical transient receptor potential (TRPC) family of ion channels. DAG is the endogenous activator of this channel, and Hyperforin is the only known TRPC6-selective activator. Although it is broadly used, Hyperforin is chemically unstable. Efforts to find a stable but pharmacologically similar TRPC6 activator resulted in the discovery of Hyp9, a simplified phloroglucinol derivative. Like Hyperforin, Hyp9 inhibits serotonin reuptake and induces neurite outgrowth. It increases calcium entry into the cell and selectively increases current through TRPC6 channels.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Evan W Weber et al.
The Journal of experimental medicine, 212(11), 1883-1899 (2015-09-24)
Leukocyte transendothelial migration (TEM) is a tightly regulated, multistep process that is critical to the inflammatory response. A transient increase in endothelial cytosolic free calcium ion concentration (↑[Ca(2+)]i) is required for TEM. However, the mechanism by which endothelial ↑[Ca(2+)]i regulates
Lu Liu et al.
Frontiers in cell and developmental biology, 8, 594283-594283 (2021-02-20)
Transient receptor potential canonical 6 (TRPC6) channel is an important non-selective cation channel with a variety of physiological roles in the central nervous system. Evidence has shown that TRPC6 is involved in the process of experimental stroke; however, the underlying

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