G5640

Globulins Cohn fraction II, III from goat

• Synonyme(s) : Vitamin D binding protein
• Numéro CAS: 68476-36-8
• Numéro CE : 270-678-2
• Numéro MDL: MFCD00164084
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.61

Propriétés

• Source biologique: goat
• Pureté: 73-90% protein basis (biuret)
• Forme: lyophilized powder
• Composition: Protein, 73-90% biuret
• Solubilité: H₂O: soluble 25 mg/mL
• Température de stockage: 2-8°C

Description

Description générale

Vitamin D binding protein (DBP) is a polymorphic protein that specifically binds to vitamin D and its metabolites. This protein belongs to the albuminoid family and is highly conserved among vertebrates. The gene encoding DBP is mapped to human chromosome 4q11-q13. It is predominantly produced in the liver and is also expressed in the kidney, endocrine pancreatic cells, fat cells, and testis.

Application

Globulins were used in Biotin/avidin formulations.

Actions biochimiques/physiologiques

Vitamin D binding protein (DBP) specifically binds and transports vitamin D and its metabolites with high affinity. It promotes fibrillar actin clearance by binding to actin monomers. DBP also binds to unsaturated fatty acids, megalin-cubilin receptor complex, the membrane of leukocytes, and the activation of the complement C5 system. The levels of DBP indicate the free concentration of all vitamin D metabolites. Decreased levels of serum DBP are observed in liver diseases, nephrotic syndrome, malnutrition, severe acute trauma, or disease.

Autres remarques

Primarily γ-globulins

Forme physique

Lyophilized powder containing NaCl

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable