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F8182

Sigma-Aldrich

Faropenem sodium hydrate

≥98% (HPLC)

Synonyme(s) :

(5R,6S,8R,2′R)-2-(2′-tetrahydrofuryl)-6-hydroxyethylpenem-3-carboxylate sodium salt, ALP 201, Farom, Fropenem, Furopenem, SUN 5555, SY 5555, Wy 49605

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About This Item

Formule empirique (notation de Hill):
C12H14NNaO5S · xH2O
Numéro CAS:
122547-49-3
Poids moléculaire :
307.30 (anhydrous basis)
Numéro MDL:
MFCD17215925
Code UNSPSC :
12352200
ID de substance PubChem :
329799769
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Activité optique

[α]/D +120 to +130°, c = 1.0 in water

Conditions de stockage

desiccated

Couleur

white to light brown

Solubilité

H2O: ≥20 mg/mL

Auteur

Daiichi-Sankyo

Température de stockage

−20°C

Chaîne SMILES 

O.[Na+].C[C@@H](O)C1C2SC(C3CCCO3)=C(N2C1=O)C([O-])=O

InChI

1S/C12H15NO5S.Na.H2O/c1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6;;/h5-7,11,14H,2-4H2,1H3,(H,16,17);;1H2/q;+1;/p-1/t5-,6-,7+,11-;;/m1../s1

Clé InChI

FHSVCMPZCIOKGW-VIDQLUEFSA-M

Description générale

Faropenem sodium hydrate belongs to the penem group of antibiotics prescribed for oral usage. Enterobacteriaceae bacterial infections with cephalosporin resistance are susceptible to faropenem. Faropenem could be an effective antibiotic to treat urinary tract infections caused by extended-spectrum beta-lactamases (ESBL) producing bacteria.

Actions biochimiques/physiologiques

Faropenem sodium is an ultra-broad spectrum, β-lactamase resistant, β-lactam antibiotic active against both Gram-positive and Gram-negative bacteria.

Caractéristiques et avantages

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Faropenem, a new oral penem: antibacterial activity against selected anaerobic and fastidious periodontal isolates.
Milazzo I, et al.
The Journal of Antimicrobial Chemotherapy, 51(3), 721-725 (2003)
S Furukawa et al.
The Japanese journal of antibiotics, 48(2), 210-219 (1995-02-01)
1. SY5555 dry syrup (powder which is dissolved before use) was administered to 25 patients with bacterial infections (6 cases of bronchitis, 2 cases of bronchopneumonia, 1 case of pertussis, 3 cases of scarlet fever, 5 cases of tonsillitis, 3
S K Spangler et al.
Antimicrobial agents and chemotherapy, 38(11), 2599-2604 (1994-11-01)
The National Committee for Clinical Laboratory Standards agar dilution method was used to compare the in vitro activity of WY-49605 (also called SUN/SY 5555 and ALP-201), a new broad-spectrum oral penem, to those of amoxicillin, amoxicillin-clavulanate, imipenem, ciprofloxacin, cefaclor, cefpodoxime
Treatment of acute uncomplicated cystitis with faropenem for 3 days versus 7 days: multicentre, randomized, open-label, controlled trial.
Hamasuna R, et al.
The Journal of Antimicrobial Chemotherapy, 69(6), 1675-1680 (2014)
J M Woodcock et al.
The Journal of antimicrobial chemotherapy, 39(1), 35-43 (1997-01-01)
The in-vitro activity of faropenem, a novel oral penem, was studied in comparison with other beta-lactam antimicrobials against 711 recent clinical isolates including Gram-negative, Gram-positive and anaerobic bacteria. MIC data showed that faropenem was active against most members of the
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