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F6550

Sigma-Aldrich

Anti-FLIPα, C-Terminal antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonyme(s) :

Anti-CASH, Anti-CLARP, Anti-Casper, Anti-FLAME-1, Anti-I-FLICE

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About This Item

Numéro MDL:
MFCD02096351
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 55 kDa

Espèces réactives

human

Technique(s)

western blot: 0.5 μg/mL using human HeLa cell extract

Numéro d'accès UniProt

O15519

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CFLAR(8837)

Spécificité

By immunoblotting, the antibody detects human FLIPα (FLICE-inhibitory protein).

Immunogène

synthetic peptide corresponding to amino acids 447-464 of human FLIPα/FLIPL.

Application

Anti-FLIPα, C-Terminal antibody is suitable for:
  • western blotting of whole L540 cell extracts to detect c-flip activity in the regulation of NF-κB distribution and activity by 5F11 and bortezomib
  • immunohistochemistry analysis to study the optimization of c-FLIP activity in lymphoma cells
  • immunohistochemical cytoplasmic c-Flip staining to detect c-FLIP expression in Burkitt′s lymphoma (BL) may be a reliable prognostic marker
  • western blot analysis at a concentration of 0.5μg/mL using human HeLa cell extract.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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The fully human anti-CD30 antibody 5F11 activates NF-?B and sensitizes lymphoma cells to bortezomib-induced apoptosis.
Boris B et al.
Blood, 106(5) (2005)
Marie-Blanche Valnet-Rabier et al.
British journal of haematology, 128(6), 767-773 (2005-03-10)
The World Health Organization Classification of Lymphoid Neoplasms identifies Burkitt's lymphoma/leukaemia (BL) as a single entity, characterized by unique clinical and genetic features that require specific high intensity chemotherapy regimens. Although remarkable successes in the treatment of the disease have
I S van Houdt et al.
Histopathology, 51(6), 778-784 (2007-11-29)
Inhibition of apoptosis is important in the pathogenesis of lymphomas. c-FLIP, a regulator of caspase 8-mediated apoptosis, plays an important role in protecting normal B and T cells from apoptosis and possibly also in lymphomas. Because of contradictory reports about
Teruki Yanagi et al.
PloS one, 10(3), e0119404-e0119404 (2015-03-20)
While PCTAIRE1/PCTK1/Cdk16 is overexpressed in malignant cells and is crucial in tumorigenesis, its function in apoptosis remains unclear. Here we investigated the role of PCTAIRE1 in apoptosis, especially in the extrinsic cell death pathway. Gene-knockdown of PCTAIRE1 sensitized prostate cancer
Ines Müller et al.
Molecular cell, 77(5), 970-984 (2020-01-27)
Cytosolic caspase-8 is a mediator of death receptor signaling. While caspase-8 expression is lost in some tumors, it is increased in others, indicating a conditional pro-survival function of caspase-8 in cancer. Here, we show that tumor cells employ DNA-damage-induced nuclear

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