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D2189

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Recombinant CRM197 expressed in Pseudomonas fluorescens, [Glu52]- Diphtheria toxin

lyophilized powder

Synonyme(s) :

[Glu52]-Diphtheria toxin from Corynebacterium diphtheriae, CRM 197

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About This Item

Numéro CAS:
Code UNSPSC :
12352202

Forme

lyophilized powder

Niveau de qualité

Température de stockage

2-8°C

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Conditionnement

Package size based on protein content

Forme physique

Lyophilized powder containing sodium phosphate, sucrose and polysorbate 80

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


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Consulter la Bibliothèque de documents

F Micoli et al.
Vaccine, 30(5), 853-861 (2011-12-17)
A conjugate vaccine for Salmonella enterica serovar Typhi was produced by chemically linking Vi, purified from Citrobacter, to the non-toxic mutant diphtheria toxin CRM(197) via an adipic dihydrazide spacer using N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide coupling chemistry. The polysaccharide purification process was developed based
Enrico Malito et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(14), 5229-5234 (2012-03-21)
CRM197 is an enzymatically inactive and nontoxic form of diphtheria toxin that contains a single amino acid substitution (G52E). Being naturally nontoxic, CRM197 is an ideal carrier protein for conjugate vaccines against encapsulated bacteria and is currently used to vaccinate
Naoko Kunami et al.
Anticancer research, 31(7), 2483-2488 (2011-08-30)
The therapeutic outcome for T-cell acute lymphoblastic leukemia (T-ALL) remains poor; thus, novel, targeted therapies are urgently needed. Recently, we showed that heparin-binding epidermal growth factor-like growth factor (HB-EGF), a member of the EGF family, is a promising target for
Fabio Fiorino et al.
Vaccine, 30(43), 6111-6114 (2012-06-19)
Typhoid fever is a public health problem, especially among young children in developing countries. To address this need, a glycoconjugate vaccine Vi-CRM₁₉₇, composed of the polysaccharide antigen Vi covalently conjugated to the non-toxic mutant of diphtheria toxin CRM₁₉₇, is under
Geert J Schenk et al.
Journal of controlled release : official journal of the Controlled Release Society, 158(1), 139-147 (2011-10-11)
Efficient delivery of drugs to specific cellular reservoirs is of particular importance for therapeutics that are not able to pass cellular barriers and that may have unwanted side effects in off-target tissues. Heparin-binding epidermal growth factor (HB-EGF) is expressed on

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