D193

DL-α-Difluoromethylornithine hydrochloride hydrate

≥97% (NMR), solid, polyamine biosynthesis inhibitor

• Synonyme(s) : 2-(Difluoromethyl)ornithine hydrochloride hydrate, DFMO hydrochloride hydrate, Eflornithine hydrochloride hydrate
• Formule empirique (notation de Hill): C₆H₁₂F₂N₂O₂ · xHCl · yH₂O
• Numéro CAS: 70052-12-9
• Poids moléculaire : 182.17 (anhydrous free base basis)
• Numéro MDL: MFCD00242734
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278809
• Nomenclature NACRES : NA.77

Propriétés

• product name: DL-α-Difluoromethylornithine hydrochloride hydrate, solid, ≥97% (NMR)
• Pureté: ≥97% (NMR)
• Forme: solid
• Couleur: white
• Solubilité: DMSO: >10 mg/mL; H₂O: >10 mg/mL
• Chaîne SMILES: O.Cl.NCCCC(N)(C(F)F)C(O)=O
• InChI: 1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
• Clé InChI: FJPAMFNRCFEGSD-UHFFFAOYSA-N
• Informations sur le gène: human ... ODC1(4953)

Description

Description générale

Difluoromethylornithine is a fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic effects on mammalian cells and tissues.

Application

DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.

Actions biochimiques/physiologiques

Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)