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Principaux documents

D0446

Sigma-Aldrich

DS1

≥98% (HPLC)

Synonyme(s) :

4-Chloro-N-[6,8-dibromo-2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl]benzamide

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About This Item

Formule empirique (notation de Hill):
C18H10Br2ClN3OS
Numéro CAS:
Poids moléculaire :
511.62
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :

Essai

≥98% (HPLC)

Forme

powder

Conditions de stockage

desiccated

Couleur

off-white to tan

Solubilité

DMSO: >10 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

Clc1ccc(cc1)C(=O)Nc2c(nc3c(Br)cc(Br)cn23)-c4cccs4

InChI

1S/C18H10Br2ClN3OS/c19-11-8-13(20)16-22-15(14-2-1-7-26-14)17(24(16)9-11)23-18(25)10-3-5-12(21)6-4-10/h1-9H,(H,23,25)

Clé InChI

MEWSBNIVOLYKGU-UHFFFAOYSA-N

Actions biochimiques/physiologiques

δ-GABAA receptors are emerging as an important pharmacological target. DS1 potently (low nM) enhances GABA-evoked currents mediated by α4β3δ receptors. It had little effect on GABA responses mediated by α4β3γ2 receptors. At similar concentrations DS1 directly activates this receptor and is the most potent known agonist of α4β3δ receptors. This compound has an opportunity to be become an agonist golden stardard for δ-GABAA receptors.
DS1 potently (low nM) enhances GABA-evoked currents mediated by α4β3δ receptors.
DS1 potently (low nM) enhances GABA-evoked currents mediated by GABAA α4β3δ receptor subtype. At similar concentrations, it acts as a direct agonist at this receptor and is the most potent agonist known. It has little effect on GABA responses mediated by α4β3γ2 receptors.

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Mention d'avertissement

Warning

Mentions de danger

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Paul Roux et al.
The British journal of psychiatry : the journal of mental science, 209(6), 511-516 (2016-10-21)
Needs and service performance assessment are key components in improving recovery among individuals with mental disorders. To test the role of service performance as a mediating factor between severity of patients' needs and outcomes. A total of 339 adults with
Anne Listrat et al.
Foods (Basel, Switzerland), 8(3) (2019-03-16)
The sensory properties of beef are known to depend on muscle fiber and intramuscular connective tissue composition (IMCT). IMCT is composed of collagens, proteoglycans and glycoproteins. The differentiation of muscle fibers has been extensively studied but there is scarcity in
Haoran Su et al.
PloS one, 3(8), e2892-e2892 (2008-08-07)
Our recent discovery of the substituted cyclobutane Boc5, one of the first non-peptidic agonists at glucagon-like peptide-1 receptors, offers the potential of combining oral availability with full agonism capable of eliciting antidiabetic and antiobesity effects. The present study was aimed
Thomas A W Bolton et al.
IEEE transactions on medical imaging, 37(1), 230-240 (2017-09-26)
Functional magnetic resonance imaging (fMRI) provides a window on the human brain at work. Spontaneous brain activity measured during resting-state has already provided many insights into brain function. In particular, recent interest in dynamic interactions between brain regions has increased
Nicholas D Huntington et al.
The Journal of experimental medicine, 206(1), 25-34 (2008-12-24)
The in vivo requirements for human natural killer (NK) cell development and differentiation into cytotoxic effectors expressing inhibitory receptors for self-major histocompatibility complex class I (MHC-I; killer Ig-like receptors [KIRs]) remain undefined. Here, we dissect the role of interleukin (IL)-15

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