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B6936

Sigma-Aldrich

3-Benzidino-6-(4-chlorophenyl)pyridazine

≥98% (HPLC), solid

Synonyme(s) :

BCP

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About This Item

Formule empirique (notation de Hill):
C22H17N4Cl
Numéro CAS:
901773-91-9
Poids moléculaire :
372.85
Numéro MDL:
MFCD11046030
Code UNSPSC :
12352202
ID de substance PubChem :
329773289
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

solid

Couleur

light yellow

Solubilité

DMSO: >14 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

Nc1ccc(cc1)-c2ccc(Nc3ccc(nn3)-c4ccc(Cl)cc4)cc2

InChI

1S/C22H17ClN4/c23-18-7-1-17(2-8-18)21-13-14-22(27-26-21)25-20-11-5-16(6-12-20)15-3-9-19(24)10-4-15/h1-14H,24H2,(H,25,27)

Clé InChI

ABGCSSPCKSVMHI-UHFFFAOYSA-N

Actions biochimiques/physiologiques

3-Benzidino-6-(4-chlorophenyl)pyridazine is an inhibitor of delayed rectifier and transient outward potassium currents. The IC50 values for the blocking action of BCP on IKDR and IKA was calculated as 7.13 μM and 0.55 μM, respectively in acutely isolated rat hippocampal pyramidal neurons by using whole-cell patch-clamp technique. The parent compound, minaprine (Cat. No. M3157), has selective affinity for M1 muscarinic receptors and possesses memory-enhancing properties and also acts as an antidepressant.

Caractéristiques et avantages

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Richard K Sterling et al.
The American journal of gastroenterology, 114(5), 746-757 (2018-11-10)
Because most HBV/HIV co-infected patients on combination antiretroviral therapy (cART) have suppressed HBV DNA and normal liver enzymes, the histologic spectrum of liver disease in HBV/HIV coinfection is poorly defined. To address this gap in knowledge, we conducted a prospective
Thomas R Schulz et al.
Journal of medical virology, 90(2), 271-276 (2017-09-09)
Hepatitis B virus (HBV) from 76 adult immigrants in Australia from Myanmar was characterized to determine the prevalence of different HBV genotypes and subgenotypes. A mutational analysis was then performed to determine the presence of clinically significant mutations and correlate
Laura F Grice et al.
Molecular biology and evolution, 34(5), 1083-1099 (2017-01-21)
Although discriminating self from nonself is a cardinal animal trait, metazoan allorecognition genes do not appear to be homologous. Here, we characterize the Aggregation Factor (AF) gene family, which encodes putative allorecognition factors in the demosponge Amphimedon queenslandica, and trace
D Wong et al.
Alimentary pharmacology & therapeutics, 47(1), 114-122 (2017-10-13)
Hepatitis B e antigen (HBeAg) seroconversion is a treatment endpoint for HBeAg-positive CHB, and a necessary precursor to HBsAg loss. Biomarkers that predict serological outcomes would be useful. To evaluate the utility of measuring HBeAg levels for predicting HBeAg seroconversion
Ziran Zhao et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 4(11), 1700204-1700204 (2017-12-05)
In this work, a fully tin-based, mixed-organic-cation perovskite absorber (FA)
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