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A3418

Sigma-Aldrich

Anti-α1-Acid Glycoprotein antibody produced in goat

whole antiserum

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About This Item

Numéro MDL:
MFCD00162118
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

goat

Conjugué

unconjugated

Forme d'anticorps

whole antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Poids mol.

antigen 40.8 kDa (sedimentation velocity and diffusion studies)

Contient

15 mM sodium azide

Espèces réactives

human

Technique(s)

quantitative precipitin assay: 1.5 mg/mL

Numéro d'accès UniProt

P02763

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ORM1(5004)

Description générale

α-1 acid glycoprotein is a protein at 43kDa secreted mainly from the liver during acute phase reaction. Its expression is induced by cytokines and corticosteroids.
Alpha-1-acid glycoprotein (AGP) is also known as orosomucoid (ORM). It is a 41-43 kDa glycoprotein. It is one of the important acute phase proteins found in humans, rats, mice and other species. This immunosuppressive glycoprotein is composed of two isoforms, such as ORM1 and ORM2.
Goat Anti-α1-Acid Glycoprotein antibody is immunospecific for human α1-acid glycoprotein by immunoelectrophoresis versus human serum and α1-acid glycoprotein.

Immunogène

purified human α1-acid glycoprotein

Application

Goat Anti-α1-Acid Glycoprotein antibody can be used for quantitative precipitin assays at 1.5mg/ml.

Actions biochimiques/physiologiques

Abberations of orosomucoid 1 (ORM1) is linked with the pharmacokinetics of telmisartan. This plasma protein participates in the binding and transport of several drugs.

Forme physique

Supplied as a liquid containing 15mM sodium azide as preservative.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H312,H412

Conseils de prudence

P280

Classification des risques

Acute Tox. 4 Dermal - Aquatic Chronic 3

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Effect of alpha-1-acid glycoprotein binding on pharmacokinetics and pharmacodynamics
Huang Z, et al.
Current Drug Metabolism, 14(2), 226-238 (2013)
Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan
Chen WQ, et al.
Testing, 8(8) (2013)
Alpha-1-acid glycoprotein
Fournier T, et al.
Biochimica et Biophysica Acta, 1482(1-2), 157-171 (2000)
Elisabetta Razzuoli et al.
Veterinary research communications, 47(3), 1615-1627 (2023-04-11)
Canine Soft Tissue Sarcoma (STS) cell line A-72 has been largely employed for antiviral and antiproliferative studies. However, there are few information on their characteristics. Our aim was to evaluate A-72 expression level of genes and proteins involved in the
Kiwamu Nakamura et al.
Cytokine, 73(1), 8-15 (2015-02-18)
Orosomucoid (ORM, composed of two isoforms, ORM1 and ORM2) has been described as an inducer of M2 macrophages, which are cells that decrease host antibacterial innate immunities. However, it is unknown which phenotypes of M2 macrophages are induced by ORM.

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