A1895

Aurintricarboxylic acid

≥85% purity (titration), practical grade, powder

• Synonyme(s) : ATA
• Formule empirique (notation de Hill): C₂₂H₁₄O₉
• Numéro CAS: 4431-00-9
• Poids moléculaire : 422.34
• Numéro CE : 224-628-1
• Numéro MDL: MFCD00011663
• Code UNSPSC : 12171500
• ID de substance PubChem : 24278210
• Nomenclature NACRES : NA.47

Propriétés

• product name: Aurintricarboxylic acid, practical grade, ≥85% (titration), powder
• Qualité: practical grade
• Pureté: ≥85% (titration)
• Forme: powder
• Couleur: red to very dark red, and Red-Brown andBrown-Red
• Pf: 300 °C (lit.)
• Solubilité: 1 M NH4OH: 10 mg/mL
• Application(s): diagnostic assay manufacturing; hematology; histology
• Température de stockage: room temp
• Chaîne SMILES: OC(=O)c1cc(ccc1O)C(\c2ccc(O)c(c2)C(O)=O)=C3\C=CC(=O)C(=C3)C(O)=O
• InChI: 1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)
• Clé InChI: GIXWDMTZECRIJT-UHFFFAOYSA-N

Description

Application

• Aurintricarboxylic acid has been used to show its anticryptosporidial activity against Cryptosporidium parvum.
• It has been used as a test substance to identify inhibitors against coronavirus N7-MTases (guanine-N7-methyltransferase).
• It has been used as a ribonuclease inhibitor.

Actions biochimiques/physiologiques

Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca²⁺ -impermeable GluR2 receptors and inhibits calpain, a Ca²⁺ -activated protease that is activated during apoptosis.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves