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94310

Sigma-Aldrich

Uricase from Bacillus fastidiosus

lyophilized, ~9 U/mg

Synonyme(s) :

Urate oxidase

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About This Item

Numéro CAS:
9002-12-4
Numéro de classification (Commission des enzymes):
1.7.3.3 (BRENDA, IUBMB)
Numéro MDL:
MFCD00082126
Code UNSPSC :
12352204
ID de substance PubChem :
57653596
Nomenclature NACRES :
NA.54

Source biologique

Bacillus sp. (B. fastidiosus)

Forme

powder

Qualité

lyophilized

Activité spécifique

~9 U/mg

Conditions de stockage

dry at room temperature

Concentration

90—100%

Couleur

white to faint beige

Solubilité

5 mg/mL, clear, colorless to very faintly yellow (in enzyme dilution buffer)

Application(s)

detection

Température de stockage

−20°C

Chaîne SMILES 

N.OCC1OC(C(O)C1OP(O)(=O)OCC2OC(C(O)C2O)N3C=CC(=O)NC3=O)N4C=CC(=O)NC4=O

InChI

1S/C18H23N4O14P.H3N/c23-5-7-14(13(28)16(34-7)22-4-2-10(25)20-18(22)30)36-37(31,32)33-6-8-11(26)12(27)15(35-8)21-3-1-9(24)19-17(21)29;/h1-4,7-8,11-16,23,26-28H,5-6H2,(H,31,32)(H,19,24,29)(H,20,25,30);1H3

Clé InChI

VPXDHZMLJOJKOX-UHFFFAOYSA-N

Description générale

Research area: Cell signaling
Uricase is present in many organisms, such as, archaea, bacteria, and eukaryotes. The Gut microbiome is the major source of uricase, a homotetrameric enzyme containing four identical 34 kDa subunits.

Application

Uricase may be used for the determination of uric acid in biological fluids. It may be helpful in the spectrophotometric determination of purines and purine nucleosides.

Actions biochimiques/physiologiques

Uricase catalyzes the oxidation of uric acid to 5-hydroxyisourate, which subsequently forms (S)-allantoin. It is involved in purine metabolism, urate degradation and (S)-allantoin formation The absence of functional uricase in humans has significant physiological and pathophysiological implications. It has been associated with higher serum uric acid levels, leading to an increased risk of conditions related to uric acid crystallization, such as gout. Uricase has emerged as an important therapeutic target for the treatment of conditions related to hyperuricemia, such as gout.

Définition de l'unité

1 U corresponds to the amount of enzyme which oxidizes 1 μmole uric acid at pH 9.1 and 37 °C.

Autres remarques

For the determination of uric acid in biological fluids; In the spectrophotometric determination of purines and purine nucleosides.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H319,H334,H360FD

Classification des risques

Eye Irrit. 2 - Repr. 1B - Resp. Sens. 1

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Youssef M Roman
Journal of personalized medicine, 13(9) (2023-09-28)
Uric acid is the final product of purine metabolism and is converted to allantoin in most mammals via the uricase enzyme. The accumulation of loss of function mutations in the uricase gene rendered hominoids (apes and humans) to have higher
A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties
Nyborg AC, et al.
PLoS ONE (2016)
U. Naegele et al.
Methods of Enzymatic Analysis, 7, 140-140 (1985)
Berna Dalkıran et al.
Mikrochimica acta, 187(11), 609-609 (2020-10-16)
Electropolymerization of thionine (TH) on multiwalled carbon nanotube (MWCNT)-modified glassy carbon electrodes (GCE) in ethaline deep eutectic solvent (DES) was carried out for the first time, to prepare poly(thionine) (PTH) films with different nanostructured morphologies. PTH films were formed on
M.H. Jensen et al.
Methods of Enzymatic Analysis, 7, 101-101 (1985)
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