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S2002

Sigma-Aldrich

Azoture de sodium

Sodium azide

ReagentPlus®, ≥99.5%

Synonyme(s) :

Acide hydrazoïque sodium salt

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5 G
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25 G
53,90 $
100 G
103,00 $
500 G
250,00 $
2 KG
798,00 $
25 KG
8 630,00 $

20,00 $

Date d'expédition estimée le03 février 2025Détails

Devis pour commande en gros
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Changer de vue
5 G
20,00 $
25 G
53,90 $
100 G
103,00 $
500 G
250,00 $
2 KG
798,00 $
25 KG
8 630,00 $

About This Item

Formule linéaire :
NaN3
Numéro CAS:
26628-22-8
Poids moléculaire :
65.01
Numéro CE :
247-852-1
Numéro MDL:
MFCD00003536
Code UNSPSC :
12352201
ID de substance PubChem :
24899504
Nomenclature NACRES :
NA.21

20,00 $

Date d'expédition estimée le03 février 2025Détails

Devis pour commande en gros

Source biologique

synthetic (inorganic)

Niveau de qualité

200

Gamme de produits

ReagentPlus®

Essai

≥99.5%

Forme

powder

Conditions de stockage

(Tightly closed. Dry. Keep in a well-ventilated place. Do not store near acids.)

Technique(s)

cell based assay: suitable
immunohistochemistry: suitable

Couleur

white

Pf

370-425 °C

Solubilité

soluble 65 g/L at 20 °C (completely)

Adéquation

suitable for chromatography
suitable for derivatization

Application(s)

sample preparation

Chaîne SMILES 

[Na]N=[N+]=[N-]

InChI

1S/N3.Na/c1-3-2;/q-1;+1

Clé InChI

PXIPVTKHYLBLMZ-UHFFFAOYSA-N

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Description générale

L'azoture de sodium (NaN3) est un inhibiteur puissant qui se présente sous la forme d'une poudre cristalline hydrosoluble et inodore. Largement reconnu pour ses nombreuses applications différentes, il joue un rôle déterminant dans la recherche en biologie moléculaire, en culture cellulaire et en biochimie. L'azoture de sodium est couramment utilisé comme conservateur bactériostatique dans les réactifs de laboratoire et les fluides biologiques aqueux. C'est également un inhibiteur métabolique, qui inhibe la phosphorylation oxydative. En culture cellulaire, il maintient l'intégrité de vos lignées cellulaires en empêchant les contaminations microbiologiques. Ses applications s'étendent jusqu'à la biologie moléculaire, où il aide à préserver les acides nucléiques en prévision des analyses en aval, pour garantir la fidélité de vos résultats.

Application

L'azoture de sodium peut être employé en histopathologie pour préparer et conserver les échantillons de tissu.[1] [2] Il entre aussi dans la composition d'un tampon de coloration (tampon HEPES) pour l'immunomarquage d'échantillons entiers[3].
Réactions catalysées :

  • Décarboxylation oxydative[4]
  • Réactions d'addition de Michael[5]

Réactif pour la synthèse des composés suivants :
  • Copolymères bleus fluorescents[6]
  • Phosphonates de métaux[7]
  • Arènes par amination[8]
Les acétates du type Baylis-Hillman tels que le 2-(acétoxyphénylméthyl)acrylate d′éthyle peuvent subir un déplacement nucléophile par l′azoture de sodium en milieu aqueux pour former du (E)-2-azidométhyl-3-phénylpropénoate d′éthyle.[9]

Actions biochimiques/physiologiques

L'azoture de sodium est utilisé en milieu clinique comme conservateur pour diluer les fluides avant une numération des globules rouges.[10] Il évite le coiffage et l'internalisation des anticorps fluorescents liés aux membranes dans différentes applications scientifiques, notamment la cytométrie en flux.[11]

Autres remarques

Pour de plus amples informations sur notre gamme de Produits biochimiques, merci de compléter ce formulaire.

Informations légales

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Gants suggérés pour une protection contre les projections

Réf. du produit
Description
Tarif

Produit comparable

Réf. du produit
Description
Tarif

Pictogrammes

Skull and crossbonesHealth hazardEnvironment
GHS06,GHS08,GHS09

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

Organes cibles

Brain

Risques supp

EUH032

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
SDBB2097
STBJ2991
SDBB1087
SDBB0330
STBL3450

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

A critical review of published methods for analysis of red cell antigen-antibody reactions by flow cytometry, and approaches for resolving problems with red cell agglutination
Patricia A Arndt , George Garratty
Transfusion Medicine Reviews, 24(3), 174-192 (2010)
Sodium azide, a bacteriostatic preservative contained in commercially available laboratory reagents, influences the responses of human platelets via the cGMP/PKG/VASP pathway.
Russo I, et al.
Clinical Biochemistry, 41(4), 343-349 (2008)
Nucleophilic displacement by azide and cyanide on Baylis-Hillman acetates in water.
Yadav JS, et al.
Tetrahedron Letters, 46(16), 2761-2763 (2005)
Three-dimensional cellular visualization in mouse apical periodontitis using combined whole-mount staining and optical tissue clearing
Kento Tazawa , Hajime Sasaki
Journal of oral biosciences, 65, 132-135 (2023)
Calcium uptake by rat kidney mitochondria.
DeLuca HF and Engstrom GW.
Proceedings of the National Academy of Sciences of the USA, 47(11), 1744-1750 (1961)
Afficher tous les articles scientifiques apparentés

Protocoles

Antibody Purification using Protein A/G/L Agarose

Antibody purification protocols yield preparations containing endogenous IgG alongside specific antibodies.

ELISA Procedures

Detailed ELISA protocols cover indirect and capture ELISA techniques, recommending products for sandwich and indirect ELISA experiments.

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Questions

1–10 of 10 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Can I use this product (S2002) for antibody storage? What is the differences between this idem and S8032-BioXtra or 71289-BioUltra? Thanks,

    1 answer

    1. Product S2002 has not been tested for antibody storage application, the suitability will have to be determined by the end user. Product S8032 and product 71289 are both research grade sodium azide with a quality level 200. Products with a quality level 200 are designed for non-regulated applications with limited change control requirements. The major difference between the two products are the product lines associated with them.

      Product S8032 falls into the BioXtra product line. These products consist of stringent testing protocols that may include trace metal analysis and specialized suitability testing, such as hybridoma or mouse embryo culture. This product is suitable for application-specific formulations.

      Product 71289 falls into the BioXtra product line. These products consist of the finest quality products for life science with the most stringent testing protocols and highest purity. These products undergo superior manufacturing methods and product specific testing protocols that are designed to ensure quality to the highest standard. The test may include, but are not limited to, purity by gel electrophoresis, trace metal testing, and application testing.

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  4. what do you mean by Bioxtra and reagentplus? How much difference are there between two grades.

    1 answer

    1. Products that fall under the BioXtra portfolio undergo stringent testing protocols that may include trace metal analysis and specialized suitability testing, such as hybridoma or mouse embryo culture. These products include application-specific formulations such as tablets and prepared solutions.

      Products that fall under the ReagentPlus portfolio are designed for general laboratory use and have purities that are greater or equal to 95%.

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  5. What concentrations of Product S2002, Sodium azide, are used as a preservative?

    1 answer

    1. Typical concentrations for use are from 0.02 % to 0.1 %.

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  6. How can I determine the concentration of sodium azide in solution?

    1 answer

    1. Sodium azide forms a 3,5-dinitrobenzoyl derivative that can be quantified by liquid chromatography.  This method is reported in the Journal of Chromatography, 5, 597 (1982).

      Helpful?

  7. How stable are solutions of Product S2002, Sodium azide?

    1 answer

    1. At a neutral pH sodium azide solutions are fairly stable.  Under acidic conditions it is converted to hydrazoic acid, a volatile gas.

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  8. How does Product S2002, Sodium azide, inhibit certain metalloenzymes?

    1 answer

    1. The mechanism of sodium azide inhibition may be due to metal ion complexation and displacement from the enzyme.

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  9. Are there any hazards associated with the disposal of Product S2002, Sodium azide?

    1 answer

    1. Sodium azide can form metal azides.  If you have metal pipes for your plumbing, you should not dispose of solutions down them.

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  10. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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