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Halofuginone hydrobromide

VETRANAL®, analytical standard

Synonyme(s) :

trans-(±)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone monohydrobromide

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About This Item

Formule empirique (notation de Hill):
C16H17BrClN3O3 · HBr
Numéro CAS:
64924-67-0
Poids moléculaire :
495.59
Numéro MDL:
MFCD23843776
Code UNSPSC :
41116107
ID de substance PubChem :
329754239
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Gamme de produits

VETRANAL®

Durée de conservation

limited shelf life, expiry date on the label

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

Br.O[C@@H]1CCCN[C@H]1CC(=O)CN2C=Nc3cc(Br)c(Cl)cc3C2=O

InChI

1S/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2;1H/t14-,15+;/m0./s1

Clé InChI

SJUWEPZBTXEUMU-LDXVYITESA-N

Catégories apparentées

Description générale

Halofuginone hydrobromide is a synthetic alkaloid derivative of febrifugine, used widely against coccidiosis in the poultry sector. It′s a specific collagen Type I inhibitor that antagonizes or inhibits the development of new blood vessels and hence can prevent intimal hyperplasia at a vascular anastomosis.

Application

The analytical standard can be used as follows:
  • Multi-residue analysis of 11 coccidiostats in 60 feed samples by reversed phase-high performance liquid chromatography (RP-HPLC) combined with tandem mass spectrometry (MS/MS)
  • Simultaneous determination of 15 allowed and banned coccidiostats in animal feed samples by liquid chromatography-tandem mass spectrometry method (LC-MS/MS)
  • UHPLC-MS/MS method-based detection and measurement of 26 anticoccidials in surface and groundwater samples following their solid phase extraction (SPE)
  • Analysis of 48 anti-microbial compounds in pig feed samples using LC combined with high-resolution mass spectrometry (HRMS)(4)Development of an LC-MS/MS method to determine 20 coccidiostats in different animal muscle samples

Autres remarques

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informations légales

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Skull and crossbonesEnvironment
GHS06,GHS09

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
BCCL4906
BCCH6215
BCCF5060
BCCC8473
BCBW0721

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Halofuginone, a specific collagen type I inhibitor, reduces anastomotic intimal hyperplasia.
Choi, Eric T., et al.
Archives of Surgery (Chicago, Ill. : 1960), 130 (3), 257-261 (1995)
Anticoccidial effect of halofuginone hydrobromide against Eimeria tenella with associated histology
Zhang, De-Fu, et al.
Parasitology Research, 111 (2), 695-701 (2012)
Gili Wellner et al.
Histology and histopathology, 34(7), 791-801 (2019-01-11)
In Duchenne muscular dystrophy (DMD), the progressive loss of muscle and its ability to function is associated with significant fibrosis, representing the major disease complication in patients. Halofuginone, a halogenated analog of the naturally occurring febrifugine, has been shown to
Sumbul Afroz et al.
Frontiers in immunology, 11, 1831-1831 (2020-09-10)
Nutrient sensor GCN2 plays a crucial role in the maintenance of cellular homeostasis during the condition of amino acid deprivation. Dysfunction in the GCN2 signaling underlies several chronic metabolic diseases. Recent studies highlight the anti-viral potential of GCN2 against RNA
Kianna Y Elahi-Gedwillo et al.
Cancer research, 79(2), 372-386 (2018-11-08)
Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest forms of cancer, in part, because it is largely refractory to current therapies. The failure of most standard therapies in PDA, as well as promising immune therapies, may be largely ascribed
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