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01467

Sigma-Aldrich

N1-Acetylspermine trihydrochloride

≥97.0% (TLC)

Synonyme(s) :

N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]acetamide trihydrochloride

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About This Item

Formule empirique (notation de Hill):
C12H28N4O · 3HCl
Numéro CAS:
77928-70-2
Poids moléculaire :
353.76
Numéro Beilstein :
7052482
Numéro MDL:
MFCD00083219
Code UNSPSC :
12352200
ID de substance PubChem :
329747292
Nomenclature NACRES :
NA.25

Niveau de qualité

100

Pureté

≥97.0% (TLC)

Chaîne SMILES 

Cl[H].Cl[H].Cl[H].CC(=O)NCCCNCCCCNCCCN

InChI

1S/C12H28N4O.3ClH/c1-12(17)16-11-5-10-15-8-3-2-7-14-9-4-6-13;;;/h14-15H,2-11,13H2,1H3,(H,16,17);3*1H

Clé InChI

QQSPUTBJDXPUCR-UHFFFAOYSA-N

Application

N1-Acetylspermine trihydrochloride has been used in a study to determine that the human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCJ1554
BCBW6875
BCBW6912
BCBM4995V
BCBJ8286V

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Cadaverine dihydrochloride ≥99.0% (AT)

Sigma-Aldrich

33220

Cadaverine dihydrochloride

Putrescine dihydrochloride ≥98% (TLC)

Sigma-Aldrich

P7505

Putrescine dihydrochloride

Spermine analytical standard

Supelco

55513

Spermine

Spermine ≥97%

Sigma-Aldrich

S3256

Spermine

Cadaverine dihydrochloride ~98%

Sigma-Aldrich

C8561

Cadaverine dihydrochloride

Spermidine ≥99% (GC)

Sigma-Aldrich

S2626

Spermidine

Masahiro Sugimoto et al.
Bio-protocol, 10(20), e3797-e3797 (2021-03-05)
Salivary metabolomics have provided the potentials to detect both oral and systemic diseases. Capillary electrophoresis time-of-flight-mass spectrometry (CE-TOFMS) enables the identification and quantification of various charged metabolites. This method has been employed to biomarker discoveries using human saliva samples, especially
Mustapha Aouida et al.
The Journal of biological chemistry, 285(9), 6275-6284 (2009-12-29)
Bleomycin is used in combination with other antineoplastic agents to effectively treat lymphomas, testicular carcinomas, and squamous cell carcinomas of the cervix, head, and neck. However, resistance to bleomycin remains a persistent limitation in exploiting the full therapeutic benefit of
Clara Meana et al.
Journal of cellular and molecular medicine, 20(2), 302-312 (2015-11-19)
Polyamines contribute to several physiological and pathological processes, including cardiac hypertrophy in experimental animals. This involves an increase in ornithine decarboxylase (ODC) activity and intracellular polyamines associated with cyclic adenosine monophosphate (cAMP) increases. The aim of the study was to
Kira Allmeroth et al.
Journal of cell science, 134(9) (2021-05-12)
Stem cell differentiation is accompanied by increased mRNA translation. The rate of protein biosynthesis is influenced by the polyamines putrescine, spermidine and spermine, which are essential for cell growth and stem cell maintenance. However, the role of polyamines as endogenous
Leslie A Sandusky-Beltran et al.
The Journal of clinical investigation, 131(4) (2021-02-16)
Tauopathies display a spectrum of phenotypes from cognitive to affective behavioral impairments; however, mechanisms promoting tau pathology and how tau elicits behavioral impairment remain unclear. We report a unique interaction between polyamine metabolism, behavioral impairment, and tau fate. Polyamines are
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