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MAB1567A4

Sigma-Aldrich

Anti-MAG Antibody, clone 513, Alexa Fluor™ 488 Conjugate

clone 513, from mouse, ALEXA FLUOR™ 488

Synonyme(s) :

Myelin-associated glycoprotein, Siglec-4a

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Conjugué

ALEXA FLUOR™ 488

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

513, monoclonal

Espèces réactives

rat, mouse

Réactivité de l'espèce (prédite par homologie)

chicken (based on 100% sequence homology), human (based on 100% sequence homology), frog (based on 100% sequence homology), bovine (based on 100% sequence homology)

Technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable

Isotype

IgG1

Numéro d'accès NCBI

NP_002352

Numéro d'accès UniProt

P20916

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... MAG(4099)

Description générale

Myelin-associated glycoprotein (MAG), a member of the immunoglobulin superfamily, is a membrane glycoprotein of 100 kDa, and is thought to be involved in the process of myelination. Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG. MAG has been implicated in the inhibition of nerve regeneration in the CNS.

Immunogène

L2 epitope carrying glycoprotein extract of 1-2 day old chicken brain

Application

Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected MAG in rat E18 primary cortex cells.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
This Anti-MAG Antibody, clone 513, Alexa Fluor 488 Conjugate is validated for use in IC, IH for the detection of MAG.

Qualité

Evaluated by Immunohistochemistry in adult mouse brain tissue.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected MAG in adult mouse brain tissue.

Description de la cible

69 kDa calculated

Forme physique

Protein A purified
Purified mouse monoclonal IgG1 conjugated to Alexa Fluor™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Stockage et stabilité

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Remarque sur l'analyse

Control
Adult mouse brain tissue

Informations légales

ALEXA FLUOR is a trademark of Life Technologies

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Yevgeniya A Mironova et al.
eLife, 5 (2016-03-24)
Proper development of the CNS axon-glia unit requires bi-directional communication between axons and oligodendrocytes (OLs). We show that the signaling lipid phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2] is required in neurons and in OLs for normal CNS myelination. In mice, mutations of Fig4, Pikfyve
Allison Y Louie et al.
Journal of neuroinflammation, 20(1), 190-190 (2023-08-19)
Recent data suggest that myelin may be altered by physiological events occurring outside of the central nervous system, which may cause changes to cognition and behavior. Similarly, peripheral infection by non-neurotropic viruses is also known to evoke changes to cognition
Lizhao Feng et al.
iScience, 26(11), 108037-108037 (2023-10-23)
Myelin defects cause a collection of myelin disorders in the brain. The lack of human models has limited us from better understanding pathological mechanisms of myelin diseases. While human induced pluripotent stem cell (hiPSC)-derived spheroids or organoids have been used

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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