8.56044
Fmoc-Cys(Trt)-NovaSyn® TGT
for peptide synthesis, Novabiochem®
Synonyme(s) :
Trityl-Protected Cysteine Resin
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About This Item
Code UNSPSC :
12352209
Nomenclature NACRES :
NA.22
Produits recommandés
product name
Fmoc-Cys(Trt)-NovaSyn® TGT, Novabiochem®
Niveau de qualité
Gamme de produits
NovaSyn® TG
Novabiochem®
Forme
solid
Capacité de réaction
reaction type: Fmoc solid-phase peptide synthesis
Fabricant/nom de marque
Novabiochem®
Application(s)
peptide synthesis
Groupe fonctionnel
Fmoc
Température de stockage
15-25°C
Description générale
Pre-loaded resin for synthesis of peptide acids and protected peptide fragments containing a C-terminal cysteine amino-acid residue by Fmoc SPPS. The base NovaSyn® TG is a composite of low cross-linked polystyrene and 3000-4000 M.W. polyethylene glycol. Peptide synthesis is carried out at the ends of the PEG chains that have been functionalized with the hyper-acid labile 4-carboxytrityl alcohol linker. This use of this linker helps prevent racemization and β-piperidinylalanine formation during chain extension.Treatment of the peptidyl resin with 20% TFE in DCM or 1% TFA in DCM cleaves the product from the resin without affecting the standard TFA-labile side-chain protecting groups. Standard TFA cleavage releases the fully deprotected peptide.
Associated Protocols and Technical Articles:
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references:
[1] E. Atherton, et al. in "Peptides 1990, Proc. 21st European Peptide Symposium, E. Giralt & D. Andreu(Eds), 1991, Escom, Leiden, pp. 243
[2] J. Lukszo, et al. (1996) Lett. Pept. Sci., 3, 157.
[3] Y. Fujiwara, et al. (1994) Chem. Pharm. Bull., 42, 724.
[4] K. Barlos & D. Gatos in “Fmoc solid phase peptide synthesis: a practical approach”, W. C. Chan & P. D.White (Eds.), Oxford University Press, Oxford, 2000, pp. 218.
Associated Protocols and Technical Articles:
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references:
[1] E. Atherton, et al. in "Peptides 1990, Proc. 21st European Peptide Symposium, E. Giralt & D. Andreu(Eds), 1991, Escom, Leiden, pp. 243
[2] J. Lukszo, et al. (1996) Lett. Pept. Sci., 3, 157.
[3] Y. Fujiwara, et al. (1994) Chem. Pharm. Bull., 42, 724.
[4] K. Barlos & D. Gatos in “Fmoc solid phase peptide synthesis: a practical approach”, W. C. Chan & P. D.White (Eds.), Oxford University Press, Oxford, 2000, pp. 218.
Application
Applications of Fmoc-Cys(Trt)-NovaSyn® TGT include:
- the preparation of a phosphoprotein using Native Chemical Ligation (NCL).
- the preparation of a peptide intermediate for use in glycoprotein semi-synthesis.
Liaison
Replaces: 04-12-2705
Informations légales
NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Peptides 1990, Proc. 21st European Peptide Symposium, E. Giralt & D. Andreu
E. Atherton, et al. in
Proceedings, 243-243 (1991)
Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N? S acyl transfer
Masania J, et al.
Organic & Biomolecular Chemistry, 5113-5119 (2010)
K. Barlos & D. Gatos in ?Fmoc solid phase peptide synthesis: a practical approach?, W. C. Chan & P. D.
White (Eds.), Oxford University Press, Oxford
K. Barlos & D. Gatos
Solid Phase Peptide Synthesis: A Practical Approach, 218-218 (2000)
3-(1-Piperidinyl) alanine formation during the preparation of C-terminal cysteine peptides with the Fmoc/t-Bu strategy
J. Lukszo, et al.
Peptide science (Hoboken, N.J.), 3, 157-157 (1996)
Racemization-free synthesis of C-terminal cysteine-peptide using 2-chlorotrityl resin
Y. Fujiwara, et al.
Journal of Chemical and Pharmaceutical Sciences
, 42, 724-724 (1994)
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