344281-M

Forskolin, NKH477

A cell-permeable and water-soluble Forskolin derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC.

• Synonyme(s) : Forskolin, NKH477, 6-(3-Dimethylaminopropionyl)forskolin, HCl, Colforsin Daropate, HCl
• Formule empirique (notation de Hill): C₂₇H₄₃NO₈ · xHCl
• Numéro CAS: 138605-00-2
• Poids moléculaire : 509.63 (free base basis)
• Numéro MDL: MFCD00236421
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Couleur: white
• Solubilité: water: 10 mg/mL
• Température de stockage: 2-8°C
• InChI: 1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
• Clé InChI: VIRRLEDAYYYTOD-YHEOSNBFSA-N

Description

Description générale

A cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.

A cell-permeable and water-soluble Forskolin (Cat. No. 344270) derivative that is ~1.87-fold more potent than Forskolin in stimulating type V adenylate cyclase (AC) activity, while exhibiting similar potency as Forskolin toward type II & III AC (1.04- & 0.89-fold relative to Forskolin). NKH477 is shown to be orally available, blood-brain barrier permeant, and display reactivity toward a broad-spectrum of species, including human, canine, guinea pig, murine, procine, and rat.

Avertissement

Toxicity: Highly Toxic (H)

Autres remarques

Nakashima, S., et al. 2005. J. Heart Lung Transplant.24, 462.
Morinobu, S., et al. 1999. J. Neurochem.72, 2198.
Satake, K., et al. 1998. Br. J. Pharmacol.123, 753.
Toya, Y., et al. 1998. J. Mol. Cell Cardiol.30, 97.
Takeuchi, M., et al. 1995. Cardiovasc. Drug Rev.13, 339.
Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol.19, 625.
Shafiq, J., et al. 1992. Circ. Res.71, 70.
Hosono, M., et al. 1990. Eur. J. Pharmacol.183, 2110.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 2 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable