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07-810

Sigma-Aldrich

Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody

Upstate®, from rabbit

Synonyme(s) :

c-Met, cmet, HGFR, RCCP2, met proto-oncogene (hepatocyte growth factor receptor)

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

mouse, human

Réactivité de l'espèce (prédite par homologie)

rat (based on 100% sequence homology)

Fabricant/nom de marque

Upstate®

Technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

NM_000245.2

Numéro d'accès UniProt

P08581

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

phosphorylation (pTyr1230/pTyr1234/pTyr1235)

Informations sur le gène

human ... MET(4233)
mouse ... Met(17295)
rat ... Met(24553)

Spécificité

Recognizes Met phosphorylated on both Tyr1234/Tyr1235 and Tyr1230/Tyr1234/Tyr1235.

Immunogène

Peptide corresponding to amino acid region encompassing the human, mouse, and rat phospho-c-Met (Tyr1230/Tyr1234/Tyr1235)

Application

Anti-phospho-Met (Tyr1230/Tyr1234/Tyr1235) Antibody is an antibody against phospho-Met (Tyr1230/Tyr1234/Tyr1235) for use in IC, IF & WB.
Immunoblot Analysis: A 1:1000 dilution of this lot detected phospho-Met (Tyr1230/Tyr1234/Tyr1235) in RIPA lysate of HGF treated 293T cells.

Qualité

Routinely evaluated by immunoblot.

Description de la cible

155 kDa

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Federica Chiara et al.
The Journal of biological chemistry, 278(31), 29352-29358 (2003-05-15)
The met oncogene, encoding the high affinity hepatocyte growth factor receptor, is the only known gene inherited in human cancer that is invariably associated with somatic duplication of the mutant locus. Intriguingly, mutated Met requires ligand stimulation in order to
P Longati et al.
Oncogene, 9(1), 49-57 (1994-01-01)
The tyrosine kinase encoded by the MET proto-oncogene (p190MET) is the receptor for Hepatocyte Growth Factor/Scatter Factor (HGF/SF). Previous work has shown that autophosphorylation of p190MET enhances its enzymatic activity and that the major phosphorylation site is Tyr1235, located in
Kwang-Hoon Song et al.
Hepatology (Baltimore, Md.), 46(6), 1993-2002 (2007-10-10)
Bile acid synthesis in the liver is regulated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1). Transcription of the CYP7A1 gene is inhibited by bile acids and cytokines. The rate of bile acid synthesis is reduced immediately after partial hepatectomy and
Xiaobin Wang et al.
Journal of cellular and molecular medicine, 25(21), 10164-10174 (2021-10-16)
Mantle cell lymphoma (MCL) is a haematologic malignancy. The proteasome inhibitor (PI) bortezomib has been approved to treat MCL, but resistance has emerged through mechanisms that remain unclear. This study aimed to explore the mechanism of PI resistance in MCL
Helena L Palka et al.
The Journal of biological chemistry, 278(8), 5728-5735 (2002-12-12)
The receptor protein-tyrosine phosphatase (PTP) DEP-1 (CD148/PTP-eta) has been implicated in the regulation of cell growth, differentiation, and transformation, and most recently has been identified as a potential tumor suppressor gene mutated in colon, lung, and breast cancers. We have
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