780200C
Avanti
16:0 PE MCC
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt), chloroform
Synonyme(s) :
1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (sodium salt)
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About This Item
Formule empirique (notation de Hill) :
C49H86N2O11PNa
Numéro CAS:
Poids moléculaire :
933.18
Numéro MDL:
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25
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Essai
>99% (TLC)
Forme
liquid
Conditionnement
pkg of 1 × 2.5 mL (780200C-25mg)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand 780200C
Concentration
10 mg/mL (780200C-25mg)
Application(s)
advanced drug delivery
Conditions d'expédition
dry ice
Température de stockage
−20°C
Description générale
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] (16:0 PE MCC) is a lipid that comprises phosphoethanolamine linked to two palmitic acid by its phosphate group and to a maleimide moiety through its amino group. The maleimide group is a thiol acceptor and 16:0 PE MCC is a maleimide-based lipidating reagent.[1]
Application
16:0 PE MCC (1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-4-(p-maleimidomethyl)cyclohexane-carboxamide) may be used:
- in the preparation of liposomes for conjugation with human immune deficiency virus (HIV-1) envelope glycoprotein trimers[2]
- in the preparation of oligonucleotide-modified vesicles[3]
- in the functionalization of the flat silicon wafers[4]
- in lipid vesicle preparation[5]
Actions biochimiques/physiologiques
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide](1,2-Bis(diphenylphosphino)ethane (DPPE)-MCC) in functionalized liposomes aids in covalent attachment via the maleimide group. It acts as a vehicle in peptide transport studies.[6]
Conditionnement
5 mL Clear Glass Sealed Ampule (780200C-25mg)
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Mention d'avertissement
Danger
Mentions de danger
Classification des risques
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
Organes cibles
Central nervous system
Classe de danger pour l'eau (WGK)
WGK 3
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Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Malin Edvardsson et al.
Analytical chemistry, 81(1), 349-361 (2008-11-28)
A novel setup was recently developed, combining quartz crystal microbalance with dissipation monitoring (QCM-D) and optical reflectometry for measurements on one and the same surface of, for example, biomolecular adlayers and interactions ( Rev. Sci. Instr. 2008 , 79 075107
J T Elliott et al.
Bioconjugate chemistry, 11(6), 832-841 (2000-11-23)
Two maleimide-containing diacylglycerol derivatives were synthesized to permit the anchoring of short peptides and longer polypeptides to phospholipid bilayers and membranes. The maleimide was introduced at the site normally occupied by a phospholipid headgroup. The first lipid, the dipalmitoyl ester
Xiaoming Zhang et al.
Biochemical and biophysical research communications, 349(3), 920-924 (2006-09-15)
Human serum albumin (HSA) patterns have been successfully fabricated for the deposition of lipid bilayer, 1,2-dimyristoyl-sglycerophosphate (DMPA), by making use of the micro-contact printing (microCP) technique and liposome fusion. Confocal laser scanning microscopy (CLSM) results indicate that lipid bilayer has
K Gradauer et al.
Journal of controlled release : official journal of the Controlled Release Society, 172(3), 872-878 (2013-10-22)
The aim of the present study was the in vivo evaluation of thiomer-coated liposomes for an oral application of peptides. For this purpose, salmon calcitonin was chosen as a model drug and encapsulated within liposomes. Subsequently, the drug loaded liposomes
Bärbel Lorenz et al.
Biophysical chemistry, 150(1-3), 54-63 (2010-03-12)
A versatile model system to study membrane-membrane interactions in great detail is introduced. Based on colloidal probe microscopy with membrane covered spherical probes attached to tip-less cantilevers the interaction forces and adhesion energies are quantified down to single molecule resolution.
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