907197

1,4-Dinitro-1-imidazole

• Synonyme(s) : 1,4-DNIm, 1,4-Dinitroimidazole, Bifunctional bioconjugation reagent
• Formule empirique (notation de Hill): C₃H₂N₄O₄
• Numéro CAS: 19182-81-1
• Poids moléculaire : 158.07
• Numéro MDL: MFCD00297235
• Code UNSPSC : 12352005

Propriétés

• Pureté: ≥95%
• Forme: solid
• Température de stockage: −20°C
• InChI: 1S/C3H2N4O4/c8-6(9)3-1-5(2-4-3)7(10)11/h1-2H
• Clé InChI: HZPSREFSUPXCMN-UHFFFAOYSA-N

Description

Application

1,4-Dinitro-1-imidazole (1,4-DNIm) and other dinitroimidazoles were demonstrated to be bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization. In acidic to neutral aqueous conditions, 1,4-DNIms chemoselectively react with cysteines; in organic solvents in the presence of base, 1,4-DNIms chemoselectively react with lysines to form stable conjugates

Autres remarques

Dinitroimidazoles as bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable