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760978

Sigma-Aldrich

Poly(N-isopropylacrylamide) triethoxysilane terminated

average Mn 5,000

Synonyme(s) :

PNIPAM silane, polyNIPAM surface modifier

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About This Item

Formule linéaire :
(C6H11NO)nSCH2CH2CH2Si(OCH2CH3)3
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Forme

solid

Poids mol.

average Mn 5,000

PDI

≤2.5

Température de stockage

2-8°C

Description générale

Poly(N-isopropylacryamide) (PNIPAAm) is a thermoresponsive polymer. It is soluble in water below its lower critical solution temperature (LCST) (32°C) whereas it forms intramolecular hydrogen bonds thus becoming insoluble at temperatures above its LCST. PNIPAAm is functionalized with a silane coupling agent like triethoxysilane in order to reduce its surface energy thus making it hydrophobic. Triethoxysilane terminated PNIPAAm thus exhibits a switchable superhydrophobic/hydrophilic surface and are widely used as hydrophobic valves in microfluidic channels.

Application

  • Used in the synthesis of microspheres which are used in drug-delivery systems.
  • Used in fluidic devices, in protein affinity separation, and as cell culture substrates.

Caractéristiques et avantages

It exhibits swelling or deswelling behaviour with respect to external temperature which favours in nucleic acid adsorption and drug release applications.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Poly(N-isopropylacrylamide) Mn ~40,000

Sigma-Aldrich

535311

Poly(N-isopropylacrylamide)

N-Isopropylacrylamide 97%

Sigma-Aldrich

415324

N-Isopropylacrylamide

Conformal switchable superhydrophobic/hydrophilic surfaces for microscale flow control.
Chunder, A., Etcheverry, K., Londe, G., Cho, H. J., & Zhai, L.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 333(1), 187-193 (2009)
Qiang He et al.
Langmuir : the ACS journal of surfaces and colloids, 23(7), 3981-3987 (2007-02-24)
Micro- and nanopatterns of thermosensitive poly(N-isopropylacrylamide) brush on gold substrate were prepared by using chemical lithography combined with surface-initiated atom transfer radical polymerization. Self-assembled monolayers of 4'-nitro-1, 1'-biphenyl-4-thiol were structured by chemical lithography which produced cross-linked 4'-amino-1,1'-biphenyl-4-thiol monolayer within a
Poly (N-isopropylacrylamide)-coated luminescent/magnetic silica microspheres: preparation, characterization, and biomedical applications
Guo, J., Yang, W., Wang, C., He, J., & Chen, J.
Chemistry of Materials, 18(23), 5554-5562 (2006)

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