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PRKCA

protein kinase C, alpha

Synonymes:
AAG6, PKC-alpha, PKCA, PRKACA
Espèce(s):
Human PRKCA (5578), Mouse Prkca (18750), Rat Prkca (24680), Horse PRKCA (100063318), dog PRKCA (490904), Domestic Rabbit PRKCA (100037720), domestic cat PRKCA (101086433), sheep PRKCA (101110074), Zebrafish prkca (497384), chicken PRKCA (417430) ...Plus
ID UniProtKB:
P17252, B5BU22, Q15137, Q32M72, Q96RE4
ID du gène:
  • Human(5578) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
  • Mouse(18750) protein kinase C, alpha
  • Rat(24680) protein kinase C, alpha
  • Horse(100063318) protein kinase C, alpha
  • dog(490904) protein kinase C, alpha
  • Domestic Rabbit(100037720) protein kinase C, alpha
  • domestic cat(101086433) protein kinase C, alpha
  • sheep(101110074) protein kinase C, alpha
  • Zebrafish(497384) protein kinase C, alpha
  • chicken(417430) protein kinase C, alpha
  • cow(282001) protein kinase C, alpha
  • domestic guinea pig(100302324) protein kinase C, alpha
  • domestic guinea pig(100713627) protein kinase C, alpha
  • naked mole-rat(101716044) protein kinase C, alpha

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Small Molecule - Activator

Référence du produit
Description
Espèce(s)
20-133-M
PKC Lipid Activator, ,
Espèce(s)
human

Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
O1008
Acide oléique, ≥99% (GC),
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
SAB4502354
Anti-PKC α antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
SAB4502356
Anti-PKC-PAN antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
SAB4200739
Anti-Protein kinase C antibody, Mouse monoclonal, clone MC5, purified from hybridoma cell culture,
Espèces réactives
bovine, chicken, fish, human, mouse, rabbit, rat
Application
immunocytochemistry
immunofluorescence
immunoprecipitation (IP)
western blot
05-983
Anti-PKC Antibody (α, β, γ), clone M110, clone M110, Upstate®, from mouse,
Espèces réactives
human, mouse, rat
Application
ELISA
immunocytochemistry
immunoprecipitation (IP)
western blot
07-790
Anti-phospho-PKCα (Ser657/Tyr658) Antibody, Upstate®, from rabbit,
Espèces réactives
human, rabbit, rat
Application
ELISA
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
S7049
D-Sphingosine, synthetic,
Espèce(s)
rat
O6754
1-Oleoyl-2-acetyl-sn-glycerol, ≥97% (TLC), oil,
Espèce(s)
human
K1639
K-252a, from Nonomuraea longicatena, ≥98% (HPLC),
Espèce(s)
rat, human
K2015
K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%,
Espèce(s)
rat, human
C9911
(S)-(+)-camptothécine, ≥90% (HPLC), powder,
Espèce(s)
rat, mouse, human

Proteins

Référence du produit
Description
Espèce(s)
14-484-M
PKCα Protein, active, 10 µg, Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.,
Espèce(s)
human
P1782
Protein kinase Cα isozyme human, ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
Espèce(s)
human
SRP5251
PKC-α, active, GST tagged from Xanopus sp., PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)

esiRNA

Référence du produit
Description
Espèce(s)
EMU080561
MISSION® esiRNA, targeting mouse Prkca,
Espèce(s)
mouse
EHU050821
MISSION® esiRNA, targeting human PRKCA,
Espèce(s)
human

Small Molecule - Substrate

Référence du produit
Description
Espèce(s)
12-123
PKC Substrate Peptide, PKC Substrate Peptide primarily used in Kinase Assays.,
Espèce(s)
human
20-131
Cocktail de substrats pour la PKC, ,
Espèce(s)
human