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KCNA3

potassium voltage-gated channel, shaker-related subfamily, member 3

Synonymes:
HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(3738) Summary: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]
  • Mouse(16491) potassium voltage-gated channel, shaker-related subfamily, member 3
  • Rat(29731) potassium voltage-gated channel, shaker-related subfamily, member 3
  • cow(525507) potassium voltage-gated channel, shaker-related subfamily, member 3
  • domestic cat(101092201) potassium voltage-gated channel, shaker-related subfamily, member 3
  • dog(490110) potassium voltage-gated channel, shaker-related subfamily, member 3
  • chicken(404303) potassium voltage-gated channel, shaker-related subfamily, member 3
  • naked mole-rat(101719045) potassium voltage-gated channel, shaker-related subfamily, member 3
  • domestic guinea pig(100721847) potassium voltage-gated channel, shaker-related subfamily, member 3
  • sheep(101105466) potassium voltage-gated channel, shaker-related subfamily, member 3
  • Domestic Rabbit(100328945) potassium voltage-gated channel, shaker-related subfamily, member 3

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-Potassium Channel Kv1.3 Antibody, extracellular domain, Chemicon®, from rabbit,
Espèces réactives
human, rat
Application
flow cytometry
western blot
Anti-KV1.3 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry
Anti-phospho-Kv1.3/KCNA3 (pTyr135) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-KCNA3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-Potassium Channel Kv1.3 Antibody, Chemicon®, from rabbit,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
Charybdotoxin, ≥90% (HPLC),
Espèce(s)
mouse, rat, human
Guanidine hydrochloride, for molecular biology, ≥99%,
Espèce(s)
human
Guanidine hydrochloride, ≥98%,
Espèce(s)
human
Guanidine hydrochloride, ≥99% (titration), organic base and chaeotropic agent,
Espèce(s)
human
Guanidine hydrochloride, ,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human KCNA3,
Espèce(s)
human