T2803

7-Ethoxy-4-(trifluoromethyl)coumarin

Name: 7-Ethoxy-4-(trifluoromethyl)coumarin
Brand: SIGMA
Price: 544 CAD

≥98% (TLC), powder

Synonym(s):

Ethyl 4-(trifluoromethyl)umbelliferyl ether

Slide 1 of 1

Select a Size

5 MG

$544.00

Please contact Customer Service for Availability

About This Item

Empirical Formula (Hill Notation):

C₁₂H₉F₃O₃

CAS Number:

115453-82-2

Molecular Weight:

258.19

NACRES:

NA.32

PubChem Substance ID:

24900082

UNSPSC Code:

12352204

MDL number:

MFCD00467588

Beilstein/REAXYS Number:

8555209

Key Documents

View All Documentation

Product Name

7-Ethoxy-4-(trifluoromethyl)coumarin, ≥98% (TLC)

Quality Level

100

assay

≥98% (TLC)

form

powder

solubility

chloroform: 100 mg/mL, clear, colorless (Soluble in chloroform, methanol, and DMSO.)

fluorescence

λ_ex 333 nm; λ_em 415 nm in methanol

storage temp.

−20°C

SMILES string

CCOc1ccc2c(OC(=O)C=C2C(F)(F)F)c1

InChI

1S/C12H9F3O3/c1-2-17-7-3-4-8-9(12(13,14)15)6-11(16)18-10(8)5-7/h3-6H,2H2,1H3

InChI key

OLHOIERZAZMHGK-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	T3165	N0252	SML2821
Sigma-Aldrich T2803 7-Ethoxy-4-(trifluoromethyl)coumarin	Sigma-Aldrich T3165 7-Methoxy-4-(trifluoromethyl)coumarin	Sigma-Aldrich N0252 4-Nitrophenyl decanoate	Sigma-Aldrich SML2821 DiFMUP
assay ≥98% (TLC)	assay ≥99% (TLC)	assay ≥98% (TLC)	assay ≥98% (HPLC)
solubility chloroform: 100 mg/mL, clear, colorless (Soluble in chloroform, methanol, and DMSO.)	solubility acetone: 50 mg/mL, clear, colorless to faintly yellow	solubility chloroform: soluble 100 mg/mL, colorless to faintly yellow	solubility DMSO: 2 mg/mL, clear
Quality Level 100	Quality Level -	Quality Level 200	Quality Level 100
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. -	storage temp. −20°C	storage temp. room temp
fluorescence λ_ex 333 nm; λ_em 415 nm in methanol	fluorescence λ_ex 333 nm; λ_em 416 nm in methanol	fluorescence -	fluorescence -

Features and Benefits

7-Ethoxy-4-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P-450 catalyzed O-de-ethylation.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A direct, highly sensitive assay for cytochrome P-450 catalyzed O-deethylation using a novel coumarin analog.

J G DeLuca et al.

Biochemical pharmacology, 37(9), 1731-1739 (1988-05-01)

The microsomal O-deethylation of a novel coumarin analog, 7-ethoxy-4-trifluoromethylcoumarin (EFC), to a fluorescent product was characterized. Results indicate that this analog provides a rapid, convenient and highly sensitive means to assay cytochrome P-450-mediated metabolism. Like microsomal 7-ethoxycoumarin (7-EC) O-deethylation, EFC

Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing.

Xilin Li et al.

Toxicological sciences : an official journal of the Society of Toxicology, 175(2), 251-265 (2020-03-12)

Metabolism plays a key role in chemical genotoxicity; however, most mammalian cells used for in vitro genotoxicity testing lack effective metabolizing enzymes. We recently developed a battery of TK6-derived cell lines that individually overexpress 1 of 8 cytochrome P450s (CYP1A1

Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1.

Emily E Scott et al.

Chemical research in toxicology, 15(11), 1407-1413 (2002-11-20)

Until recently, all known structures of bacterial cytochromes P450 suggested that substrate access to the buried active site occurred via the F-G region, a surface loop distal to the heme cavity. However, the structure of P450 51 indicates a large

Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: a study of cell viability, morphology and drug metabolism.

Shih-Feng Lan et al.

Toxicology in vitro : an international journal published in association with BIBRA, 24(4), 1314-1323 (2010-02-23)

In this study, we have evaluated the use of ultra-sterile alginate hydrogels encapsulated with HepG2 liver cells for applications in high throughput drug screening. We have studied the cellular viability and metabolic capacity of the encapsulated cells in two different

Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6.

Chitra Sridar et al.

The Journal of pharmacology and experimental therapeutics, 301(3), 945-952 (2002-05-23)

Tamoxifen is primarily used in the treatment of breast cancer. It has been approved as a chemopreventive agent for individuals at high risk for this disease. Tamoxifen is metabolized to a number of different products by cytochrome P450 enzymes. The

View All Related Papers

Global Trade Item Number

SKU	GTIN
T2803-5MG	04061832910253

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

7-Ethoxy-4-(trifluoromethyl)coumarin