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T0656

Sigma-Aldrich

1,3,4,6-Tetrachloro-3α,6α-diphenylglycouril

Synonym(s):

Iodo-Gen®, NSC 4462

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About This Item

Empirical Formula (Hill Notation):
C16H10Cl4N4O2
CAS Number:
51592-06-4
Molecular Weight:
432.09
MDL number:
MFCD00027367
UNSPSC Code:
12352101
PubChem Substance ID:
24899904
NACRES:
NA.22
Pricing and availability is not currently available.

storage temp.

2-8°C

Quality Level

100

SMILES string

ClN1C(=O)N(Cl)C2(N(Cl)C(=O)N(Cl)C12c3ccccc3)c4ccccc4

InChI

1S/C16H10Cl4N4O2/c17-21-13(25)23(19)16(12-9-5-2-6-10-12)15(21,11-7-3-1-4-8-11)22(18)14(26)24(16)20/h1-10H

InChI key

FJQZXCPWAGYPSD-UHFFFAOYSA-N

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Related Categories

Application

Iodination reagent used in radioiodination acting as an oxidative agent

Reagent involved in comparison studies with chloramine-T

Reagent used for oxidation of urazoles

Legal Information

Iodo-Gen is a registered trademark of Pierce Biotechnology, Inc.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000213687
0000213687
0000203102
0000203102
0000145944

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Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.
P J Fraker et al.
Biochemical and biophysical research communications, 80(4), 849-857 (1978-02-28)
P K Garg et al.
Bioconjugate chemistry, 6(4), 493-501 (1995-07-01)
The F(ab')2 fragment of monoclonal antibody (MAb) Me1-14 was labeled with 125I using the Iodogen method and by reaction with N-succinimidyl 3-[125I]iodobenzoate (SIB). The labeled catabolites generated after exposure to tissue homogenates in vitro and following administration of labeled F(ab')2
Ganesan Vaidyanathan et al.
Nuclear medicine and biology, 29(1), 1-11 (2002-01-12)
Monoclonal antibodies (mAbs) such as the tumor-specific anti-epidermal growth factor receptor variant III (EGFRvIII) that are internalized and degraded after cell binding necessitate the use of radioiodination methods that minimize the loss of radioactivity from the tumor cell after intracellular
Ly Tran et al.
Cancer biotherapy & radiopharmaceuticals, 24(1), 103-110 (2009-02-27)
The aim of this study was to develop a safe and simple radiolabeling and purification procedure for high-dose (131)I-rituximab for treatment of patients with non-Hodgkin's lymphoma. As the starting point, the conventional Iodogen-coated vial method was applied. After the iodogen-coated
G W Visser et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 42(3), 509-519 (2001-05-05)
A novel, facile procedure for efficient coupling of high doses of (131)I to monoclonal antibodies (MAbs) was developed with minimal chemical and radiation damage. To diminish the radiation and chemical burden during labeling, iodination was performed in a large reaction
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