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SML1061

Sigma-Aldrich

PF-04856264

≥98% (HPLC)

Synonym(s):

3-Cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-2-thiazolyl-benzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C20H15N5O3S2
CAS Number:
1235397-05-3
Molecular Weight:
437.49
MDL number:
MFCD28124397
UNSPSC Code:
12352200
PubChem Substance ID:
329825643
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=S(C(C=C1)=CC(C#N)=C1OC2=CC=CC=C2C3=CC=NN3C)(NC4=NC=CS4)=O

InChI

1S/C20H15N5O3S2/c1-25-17(8-9-23-25)16-4-2-3-5-19(16)28-18-7-6-15(12-14(18)13-21)30(26,27)24-20-22-10-11-29-20/h2-12H,1H3,(H,22,24)

InChI key

MKSKJVIBSRUWSZ-UHFFFAOYSA-N

Biochem/physiol Actions

PF-04856264 is a potent, selective inhibitor of the human Nav1.7 voltage gated sodium channel (IC50 = 28 nM). PF-04856264 blocks mouse Nav1.7 (IC50 = 131 nM) but has low potency against the rat Nav1.7 channel (IC50 = 4.2 mM).

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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