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Key Documents

R0950000

Rifamycin S

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1,4-Dideoxy-1,4-dihydro-1,4-dioxorifamycin

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100 MG
$205.00

About This Item

Empirical Formula (Hill Notation):
C37H45NO12
CAS Number:
13553-79-2
Molecular Weight:
695.75
UNSPSC Code:
41116107
NACRES:
NA.24

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grade

pharmaceutical primary standard

API family

rifamycin, rifampicin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N1C2=CC(=O)c3c4c(c(c(c3C2=O)O)C)O[C@](O\C=C\[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C1=O)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C

InChI

1S/C37H45NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,41-43H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1

InChI key

BTVYFIMKUHNOBZ-ODRIEIDWSA-N

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Rifamycin S EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Health hazardEnvironment
GHS08,GHS09

Signal Word

Warning

Hazard Statements

H371,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 2

Target Organs

Liver

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

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C Bartolucci et al.
Farmaco (Societa chimica italiana : 1989), 50(9), 587-593 (1995-09-01)
Three types of open ansa-chain rifamycin S derivatives have been prepared: derivatives with the ansa-chain open at C(29) and the original dihydrofuranone ring; derivatives with the ansa-chain open at C(29) and a furane ring; derivatives with the ansa-chain at open
S K Arora
Journal of medicinal chemistry, 28(8), 1099-1102 (1985-08-01)
The crystal and molecular structure of the DNA-dependent RNA polymerase inhibiting antibiotic rifamycin S (C37H45O12N) as a dihydrate has been determined, and the conformation necessary for activity has been correlated with those of other active rifamycins. The orthorhombic unit cell
U C Banerjee
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology, 21(5), 675-683 (1993-01-01)
Rifamycin oxidase of Curvularia lunata was immobilized on alginate gel. The pH and temperature optima of the immobilized enzyme preparation were 6.5 and 50 degrees C, respectively. Transformation reaction was carried out with the immobilized enzyme preparation. It took 8
O Ghisalba et al.
The Journal of antibiotics, 35(1), 74-80 (1982-01-01)
The transformation of rifamycin S into rifamycins B and L was reinvestigated in order to establish more detailed pathways. Our results exclude rifamycin O as a common progenitor in the biosyntheses of rifamycins B and L. Rifamycins B and L
Chemical modification of the amide group of rifamycin S.
M Taguchi et al.
Chemical & pharmaceutical bulletin, 33(5), 2133-2136 (1985-05-01)
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