8.52224

Fmoc-Leu-OPfp

Novabiochem^®

• Synonym(s): Fmoc-Leu-OPfp, N-α-Fmoc-L-leucine pentafluorophenyl ester
• Empirical Formula (Hill Notation): C₂₇H₂₂F₅NO₄
• CAS Number: 86060-88-0
• Molecular Weight: 519.46
• MDL number: MFCD00065658
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• Assay: ≥97.5% (HPLC)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• mp: 101-115 °C
• application(s): peptide synthesis
• functional group: Fmoc
• storage temp.: 15-25°C
• InChI: 1S/C27H22F5NO4/c1-13(2)11-19(26(34)37-25-23(31)21(29)20(28)22(30)24(25)32)33-27(35)36-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,33,35)/t19-/m0/s1
• InChI key: NTQJCLLWLHKJLU-IBGZPJMESA-N

Description

General description

Pre-formed pentafluorophenyl ester for coupling of leucine amino-acid residues by Fmoc SPPS. Use enables bromophenol blue monitoring of amide bond formation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Linkage

Replaces: 04-12-1510

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in chloroform): -27.5 - -22.5 °
DCU (DC (0003)): ≤ 2 %
Solubility (0.5 mmole in 3 ml DMF): clearly soluble
Assay (HPLC, area%): ≥ 97.5 % (a/a)

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315
• Precautionary Statements: P264 - P280 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3