311203

N^G,N^G-Dimethyl-L-arginine, Dihydrochloride

A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo.

• Synonym(s): ADMA, 2HCl, N^G,N^G-Dimethyl-L-arginine, Dihydrochloride
• Empirical Formula (Hill Notation): C₈H₁₈N₄O₂ · 2HCl
• CAS Number: 220805-22-1
• Molecular Weight: 275.18
• UNSPSC Code: 12352209
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (TLC)
• form: amorphous solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 50 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
• InChI key: SYLNVYJOPZWPJI-ILKKLZGPSA-N

Description

General description

A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.

Endogenous reversible inhibitor of nitric oxide synthesis in vitro and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
NOS in vitro

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 2-3 µM inhibiting nitric oxide synthase in vitro

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Closs, E.I., et al. 1997. Nitric Oxide1, 65.
Faraci, F.M., et al. 1995. Am. J. Physiol.269, H1522.
Gardiner, S.M., et al. 1993. Br. J. Pharmacol. 110, 1457.
Kotani, K., et al. 1992. J. Neurochem.58, 1127.
Vallance, P., et al. 1992. Lancet339, 572.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable