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QBD10008

Sigma-Aldrich

Biotin-dPEG®12-TFP ester

Synonym(s):

Polyethylene glycol

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About This Item

Empirical Formula (Hill Notation):
C43H69F4N3O16S
Molecular Weight:
992.08
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22

Assay

>90%

form

solid or viscous liquid

reaction suitability

reaction type: Biotinylations
reaction type: Biotinylations
reactivity: amine reactive

reagent type: cross-linking reagent

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCCC1C2NC(NC2CS1)=O)=O)OC3=C(C(F)=CC(F)=C3F)F

Features and Benefits

Biotin-dPEG®12-TFP ester has 2,3,5,6-tetrafluorophenyl (TFP) moiety whcih hydrolyze more slowly than NHS esters in aqueous media and is more reactive towards amines than NHS esters. The single molecular weight Biotin-dPEG®12-TFP ester has a long spacer of precise length (47.6 Å) between the biotin moiety and the labeled molecule. This dPEG spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the PEG spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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