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GW7647

Name: GW7647
Brand: SIGMA

≥98% (HPLC), Potent human PPARα agonist

Synonym(s):

2-(4-(2-(1-Cyclohexanebutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₄₆N₂O₃S

CAS Number:

265129-71-3

Molecular Weight:

502.75

UNSPSC Code:

12352200

PubChem Substance ID:

24278790

NACRES:

NA.77

MDL number:

MFCD06798379

Assay:

≥98% (HPLC)

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Properties

Product Name

GW7647, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

color

white

solubility

DMSO: soluble 16 mg/mL, H₂O: insoluble

SMILES string

CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3)cc1)C(O)=O

InChI

1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)

InChI key

PKNYXWMTHFMHKD-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465)

Description

Application

GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand:

in defatting medium to treat primary human hepatocytes[1]
to test its effect on the glycolytic function in cardiomyocytes[2]
to test its effect on infant mouse heart[2]
in breast cancer MDA-MB-231 cells to activate PPARs[3]

Biochem/physiol Actions

GW7647 reduces serum triglyceride levels and enhances hepatic expression of genes associated with β-oxidation.[4] Usage of GW7647 along with metformin in conditions of liver steatosis or injury improves the enzymatic levels of aspartate transaminase (AST) and alanine transaminase (ALT) in serum.[4]

Potent human PPARα agonist. Use to study the biology of PPARα receptor in human cells.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold for research purposes only under agreement from GlaxoSmithKline

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Show Differences

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This Item	G3295	C5749	M5449
Sigma-Aldrich G6793 GW7647	Sigma-Aldrich G3295 GW0742	Sigma-Aldrich C5749 CGP 52608	Sigma-Aldrich M5449 MKT-077
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98%	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility DMSO: soluble 16 mg/mL, H₂O: insoluble	solubility DMSO: >5 mg/mL, H₂O: insoluble	solubility DMSO: >30 mg/mL, H₂O: insoluble	solubility H₂O: 10 mg/mL, clear
color white	color white	color -	color orange to red
Gene Information human ... PPARA(5465)	Gene Information human ... PPARA(5465), PPARD(5467), PPARG(5468)	Gene Information -	Gene Information -

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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