T9265
Thyrotropic hormone from human pituitary
lyophilized powder, ≥6.2 IU/mg (immunoassay, non-sterile)
Synonym(s):
hTSH, TSH, Thyroid stimulating hormone
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About This Item
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biological source
human pituitary glands
Quality Level
sterility
non-sterile
form
lyophilized powder
specific activity
≥6.2 IU/mg (immunoassay, non-sterile)
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
cell culture | mammalian: suitable
impurities
HIV-1/HIV-2, tested negative
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... TSHB(7252) , TSHR(7253)
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General description
Research area: Cell Signaling
Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family. Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.
Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family. Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.
Application
Thyrotropic hormone from human pituitary has been used as a supplement in the fetal thyroid organoid culture medium for stimulating maturation. It has also been used as a medium supplement for primary cell culture, and is used further to study the molecular mechanisms of estrogen-mediated growth stimulation of human thyroid tumor cells.
Biochem/physiol Actions
In children, thyroid hormones are very much essential for the normal cognition and neurodevelopment. Thyroid-stimulating hormone (TSH) test is mainly used to diagnose thyroid function.
The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer celllines.TSHR activated by TSH activates both the adenosine 3′,5′-cyclic monophosphate (cAMP) pathway (via Gsa) and the phosphoinositol/calcium (IP/Ca2+; via Gq) second messenger signaling pathway by interacting with Gs and Gq G-proteins. In mature adipocytes, TSH aids in lipid metabolism by inhibiting fatty acid synthase (FASN) expression via, activating protein kinase A (PKA)-dependent phosphorylation of extracellular signal-regulated kinases/p42/p44 (ERK1/2), and c-Jun N-terminal kinase (JNK).
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
Packaging
Package size based on hormone
Physical form
Contains hormone and salts from approx. 0.1 mL of 0.05 M phosphate buffer, pH 7.4.
antibody
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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J Carretero et al.
Histology and histopathology, 4(1), 71-76 (1989-01-01)
The TSH-producing adenohypohyseal cells of Wistar rats were studied after treatment with orally administered methymazole by the PAP immunocytochemical method. These cells were compared with those of normal animals. The effects of methymazole were different in the females to those
Physiology, Thyroid Stimulating Hormone
Pirahanchi Y, et al.
StatPearls [Internet] (2022)
Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
D Manole et al.
The Journal of clinical endocrinology and metabolism, 86(3), 1072-1077 (2001-03-10)
Thyroid tumors are about 3 times more frequent in females than in males. Epidemiological studies suggest that the use of estrogens may contribute to the pathogenesis of thyroid tumors. In a very recent study a direct growth stimulatory effect of
Jianqing Liang et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 9(9), e2105568-e2105568 (2022-01-23)
Euthyroidism is of profound importance for lifetime health. However, the early diagnosis or therapeutics of thyroid developmental defects has not been established, mainly due to limited understanding of human thyroid development and a lack of recapitulating research model. Herein, the
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