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H0800000

Homatropine hydrobromide

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

DL-Homatropine hydrobromide, DL-endo-α-Hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide, Tropine mandelate hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C16H21NO3 · HBr
CAS Number:
51-56-9
Molecular Weight:
356.25
MDL number:
MFCD00012676
UNSPSC Code:
41116107
PubChem Substance ID:
329815135
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

homatropine

manufacturer/tradename

EDQM

mp

214-217 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Br.CN1C2CCC1CC(C2)OC(=O)C(O)c3ccccc3

InChI

1S/C16H21NO3.BrH/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;/h2-6,12-15,18H,7-10H2,1H3;1H

InChI key

DWSGTFTVBLXELC-UHFFFAOYSA-N

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General description

Homatropine hydrobromide is an anticholinergic agent and is commonly used as a mydriatic and cycloplegic drug in ophthalmology.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Amol Tamhane et al.
Ophthalmology, 112(11), 1963-1969 (2005-10-04)
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Bilateral, recurrent, or chronic anterior uveitis requires a diagnostic evaluation to rule out any systemic cause. An understanding of the possible etiologies and their diagnostic criteria is needed to manage these patients. Treating any systemic cause can decrease the recurrent
Homatropine and psychosis in Weill-Marchesani syndrome.
Anjaiah Madugula et al.
Journal of the American Academy of Child and Adolescent Psychiatry, 45(7), 769-770 (2006-07-13)
Ritika Sachdev et al.
Ocular immunology and inflammation, 19(5), 343-345 (2011-08-13)
To report three cases of bilateral microbial keratitis in eyes with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) induced by highly active antiretroviral therapy (HAART) in patients of acquired immune deficiency syndrome (AIDS). A case series. A detailed clinical
Brian M Thome et al.
Electrophoresis, 28(10), 1477-1487 (2007-05-12)
True moving bed electrophoresis has been shown to be an effective technique for the bench-scale separation of enantiomers, and it is desired to increase the maximum possible throughput attainable with the process by using electric field gradients. Homatropine enantiomer separations
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