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880344P

Avanti

OChemsPC

Avanti Research™ - A Croda Brand 880344P, powder

Synonym(s):

1-oleoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C57H100NO10P
CAS Number:
155401-41-5
Molecular Weight:
990.38
UNSPSC Code:
51191904
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 25 mg (880344P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880344P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=P([O-])(OCC[N+](C)(C)C)OC[C@H](OC(CCC(OC1CC[C@]2(C)C(C1)=CCC3C2CC[C@]4(C)C3CC[C@H]4[C@@H](C)CCCC(C)C)=O)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O

Application

OChemsPC might be used to study its pharmacokinetic and biodistribution patterns in comparison with phospholipid-cholesterol liposomes.

Packaging

5 mL Amber Glass Screw Cap Vial (880344P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

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A robust and quantitative method for tracking liposome contents after intravenous administration
Kohli AG, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 176, 86-93 (2014)
F Foglia et al.
Langmuir : the ACS journal of surfaces and colloids, 27(13), 8275-8281 (2011-06-04)
Langmuir isotherm, neutron reflectivity, and small angle neutron scattering studies have been conducted to characterize the monolayers and vesicular bilayers formed by a novel chimeric phospholipid, ChemPPC, that incorporates a cholesteryl moeity and a C-16 aliphatic chain, each covalently linked
Zhaohua Huang et al.
Angewandte Chemie (International ed. in English), 48(23), 4146-4149 (2009-05-09)
Extreme makeover of cholesterol: Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer-stabilizing effect of free cholesterol but prevents its transfer from the
Maryam Iman et al.
International journal of pharmaceutics, 408(1-2), 163-172 (2011-02-01)
1,2-Di-stigma-steryl-hemi-succinoyl-sn-glycero-3-phosphocholine (DSHemsPC) is a new lipid in which two molecules of stigmasterol (an inexpensive plant sterol) are covalently linked via a succinic acid to glycerophosphocholine. Since amphotericin B (AmB) interacts with sterols, we postulated that DSHemsPC could be used in
Zhaohua Huang et al.
Journal of the American Chemical Society, 130(46), 15702-15712 (2008-10-28)
We synthesized a family of sterol-modified glycerophospholipids (SML) in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative position contains an aliphatic chain. The SML were used to explore how anchoring cholesterol to a phospholipid

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